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Rejuvenation of aged progenitor cells by exposure to a young systemic environment
The decline of tissue regenerative potential is a hallmark of ageing and may be due to age-related changes in tissue-specific stem cells. A decline in skeletal muscle stem cell (satellite cell)Expand
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Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis
The regenerative potential of skeletal muscle declines with age, and this impairment is associated with an increase in tissue fibrosis. We show that muscle stem cells (satellite cells) from aged miceExpand
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The ageing systemic milieu negatively regulates neurogenesis and cognitive function
In the central nervous system, ageing results in a precipitous decline in adult neural stem/progenitor cells and neurogenesis, with concomitant impairments in cognitive functions. Interestingly, suchExpand
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Notch-Mediated Restoration of Regenerative Potential to Aged Muscle
A hallmark of aging is diminished regenerative potential of tissues, but the mechanism of this decline is unknown. Analysis of injured muscle revealed that, with age, resident precursor cellsExpand
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The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis.
We have studied the role of Notch-1 and its antagonist Numb in the activation of satellite cells during postnatal myogenesis. Activation of Notch-1 promoted the proliferation of myogenic precursorExpand
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A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis.
The temporal switch from progenitor cell proliferation to differentiation is essential for effective adult tissue repair. We previously reported the critical role of Notch signaling in theExpand
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Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris
Here we present a compendium of single-cell transcriptomic data from the model organism Mus musculus that comprises more than 100,000 cells from 20 organs and tissues. These data represent a newExpand
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Molecular regulation of stem cell quiescence
Subsets of mammalian adult stem cells reside in the quiescent state for prolonged periods of time. This state, which is reversible, has long been viewed as dormant and with minimal basal activity.Expand
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Geroscience: Linking Aging to Chronic Disease
Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically increasing and that aging is the greatest risk factor for aExpand
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mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert
A unique property of many adult stem cells is their ability to exist in a non-cycling, quiescent state. Although quiescence serves an essential role in preserving stem cell function until the stemExpand
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