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Principles of gene therapy.
Genes are specific sequences of bases that encode instructions to make proteins. When genes are altered so that encoded proteins are unable to carry out their normal functions, genetic disorders canExpand
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Intermediary metabolism of mycobacteria.
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Deoxyribonucleic acid replication time in Mycobacterium tuberculosis H37 Rv
The DNA increment method, designed for measuring the increment in the amount of DNA after inhibition of initiation of fresh rounds of replication initiation was employed to measure the rate ofExpand
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Studies on 1-methyl adenine transfer RNA methyltransferase of Mycobacterium smegmatis
The presence of 1-methyl adenine in transfer RNA is a feature that Mycobacterium smegmatis shares with only a few other prokaryotes. The enzyme 1-methyl adenine tRNA methyl transferase from thisExpand
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Dual control of lysogeny by bacteriophage P22: an antirepressor locus and its controlling elements.
Two distantly linked clusters of genes on the Salmonella typhimurium phage P22 chromosome are involved in the control of lysogeny and superinfection immunity. One cluster consists of genes cl, ~2,Expand
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Deoxyribonucleic acid methylation in mycobacteria.
Deoxyribonucleic acid modification in six strains of mycobacteria was investigated. The presence of 5-methylcytosine in the virulent strain Mycobacterium tuberculosis H37Rv and its absence in theExpand
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Purification and properties of DNA-dependent RNA polymerase from Mycobacterium tuberculosis H37RV.
RNA polymerase (nucleosidetriphosphate: RNA nucleotidyltransferase DNA-dependent), EC 2.7.7.6) was purified approximately 200 fold from Mycobacterium tuberculosis H37RV cells. The purified enzyme hasExpand
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Effect of age on the enzymes of tricarboxylic acid and related cycles in Mycobacterium tuberculosis H37Rv.
In Mycobacterium tuberculosis H37Rv, the activities of all the enzymes of the tricarboxylic acid cycle decreased after 14–21 days of incubation, whereas that of isocitrate lyase increasedExpand
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