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Endothelial function and dysfunction: testing and clinical relevance.
Atherosclerosis begins in childhood, progresses silently through a long preclinical stage, and eventually manifests clinically, usually from middle age. Over the last 30 years, it has become clearExpand
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Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes.
Type 1 diabetes is associated with reduced vascular repair, as indicated by impaired wound healing and reduced collateral formation in ischemia. Recently, endothelial progenitor cells (EPCs) haveExpand
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Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetes.
BACKGROUND Microalbuminuria is an early predictor of diabetic nephropathy and premature cardiovascular disease. We investigated whether treatment with an angiotensin-receptor blocker (ARB) wouldExpand
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Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation.
OBJECTIVES We sought to evaluate whether increased sympathetic outflow may interfere with flow-mediated dilation (FMD). BACKGROUND Endothelial function, assessed as FMD, is frequently used as anExpand
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Stent placement in patients with atherosclerotic renal artery stenosis and impaired renal function: a randomized trial.
BACKGROUND Little is known about the efficacy and safety of renal artery stenting in patients with atherosclerotic renal artery stenosis (ARAS) and impaired renal function. OBJECTIVE To determineExpand
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Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.
In hypercholesterolemia, impaired nitric oxide activity has been associated with increased nitric oxide degradation by oxygen radicals. Deficiency of tetrahydrobiopterin, an essential cofactor ofExpand
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Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade.
BACKGROUND The role of endothelin (ET)-1 in maintenance of basal vascular tone has been demonstrated by local and systemic vasodilatation to endothelin receptor antagonists in humans. Although theExpand
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Thrombosis and hemostasis in renal disease.
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Postprandial recruitment of neutrophils may contribute to endothelial dysfunction Published, JLR Papers in Press, December 16, 2002. DOI 10.1194/jlr.M200419-JLR200
Atherosclerosis is a low-grade inflammatory disease involving leukocytes, lipids, and glucose leading to endothelial dysfunction. Since activation of neutrophils by triglycerides and glucose has beenExpand
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Expression of connective tissue growth factor in human renal fibrosis.
Chronic renal failure may occur in etiologically diverse renal diseases and can be caused by hemodynamic, immunologic and metabolic factors. Initial damage may evoke irreversible scarring, whichExpand
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