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Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine.
CD8+ cytotoxic T lymphocytes (CTLs) are critical for protection against intracellular pathogens but often have been difficult to induce by subunit vaccines in animals. DNA vaccines elicit protective… Expand
A potent antitumour quinazoline inhibitor of thymidylate synthetase: synthesis, biological properties and therapeutic results in mice.
- T. R. Jones, A. Calvert, A. Jackman, S. Brown, M. Jones, K. Harrap
- European journal of cancer
Abstract We describe the synthesis and some biological properties of N-(4-N-[2-amino-4-hydroxy-6-quinazolinyl)methyl]prop-2-ynylaminobenzoyl)- l -glutamic acid (CB 3717), a potent antifolate… Expand
Boosting with recombinant vaccinia increases immunogenicity and protective efficacy of malaria DNA vaccine.
- M. Sedegah, T. R. Jones, +4 authors S. Hoffman
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 23 June 1998
To enhance the efficacy of DNA malaria vaccines, we evaluated the effect on protection of immunizing with various combinations of DNA, recombinant vaccinia virus, and a synthetic peptide.… Expand
Stability of within-host–parasite communities in a wild mammal system
- S. Knowles, A. Fenton, O. Petchey, T. R. Jones, R. Barber, A. B. Pedersen
- Biology, Medicine
- Proceedings of the Royal Society B: Biological…
- 7 July 2013
Simultaneous infection by multiple parasite species is ubiquitous in nature. Interactions among co-infecting parasites may have important consequences for disease severity, transmission and… Expand
Fibronectin and glial fibrillary acidic protein expression in normal human brain and anaplastic human gliomas.
Abstract The expression of fibronectin (FN), an extracellular matrix glycoprotein with adhesive and opsonic properties, was examined in normal and neoplastic human central nervous system tissues. In… Expand
Molecular Epidemiology and Characterization of Campylobacter spp. Isolated from Wild Bird Populations in Northern England
- L. Hughes, M. Bennett, +9 authors J. Chantrey
- Biology, Medicine
- Applied and Environmental Microbiology
- 13 March 2009
ABSTRACT Campylobacter infections have been reported at prevalences ranging from 2 to 50% in a range of wild bird species, although there have been few studies that have investigated the molecular… Expand
Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys.
Synthetic peptide and recombinant protein vaccines are optimally immunogenic when delivered with an effective adjuvant. Candidate vaccines currently insufficiently immunogenic may induce a protective… Expand
A peptide derived from the nonreceptor binding region of urokinase plasminogen activator (uPA) inhibits tumor progression and angiogenesis and induces tumor cell death in vivo
- Y. Guo, A. Higazi, +7 authors S. Rabbani
- Chemistry, Medicine
- FASEB journal : official publication of the…
- 1 July 2000
Urokinase plasminogen activator (uPA) plays an important role in the progression of several malignancies including breast cancer. We have identified a noncompetitive antagonist of the uPA‐uPAR… Expand
A longitudinal study of an endemic disease in its wildlife reservoir: cowpox and wild rodents.
Cowpox is an orthopoxvirus infection endemic in European wild rodents, but with a wide host range including human beings. In this longitudinal study we examined cowpox in two wild rodent species,… Expand
Diagnosis of malaria in the field by fluorescence microscopy of QBC capillary tubes.
- J. K. Baird, Purnomo, T. R. Jones
- Biology, Medicine
- Transactions of the Royal Society of Tropical…
The diagnostic performance of commercial capillary tubes containing acridine orange dye (QBC) was compared with the standard diagnosis of malaria by microscopical examination of Giemsa-stained thick… Expand