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Low blood ISG15 mRNA and progesterone levels are predictive of non-pregnant dairy cows.
- Hyungchul Han, K. Austin, L. Rempel, T. R. Hansen
- Medicine, BiologyThe Journal of endocrinology
- 1 November 2006
It is concluded that detection of low blood ISG15 mRNA levels during serial collection from days 17 to 25 serves as an accurate indicator of cows that are not pregnant, thus allowing re-synchronization and insemination.
Uterine-conceptus interactions and reproductive failure in cattle.
Expression of interferon (IFN)-stimulated genes in extrauterine tissues during early pregnancy in sheep is the consequence of endocrine IFN-tau release from the uterine vein.
It is concluded that uterine vein releases IFN-tau, which induces ISG in extrauterine tissues such as the CL during the time of maternal recognition of pregnancy.
Regulation of interferon-stimulated genes in peripheral blood leukocytes in pregnant and bred, nonpregnant dairy cows.
Results clearly indicated that components of the innate immune response are activated in PBL during the period of pregnancy recognition and early embryo signaling.
Mechanism of action of interferon-tau in the uterus during early pregnancy.
- T. R. Hansen, K. Austin, D. Perry, J. Pru, M. Teixeira, G. Johnson
- BiologyJournal of reproduction and fertility. Supplement
- 5 April 2019
Induction of signal transducer and activator of transcription 1 (STAT-1), STAT-2 and interferon regulatory factor 1 (IRF-1) transcription factors is the prelude to maternal recognition of pregnancy in ruminants.
Endometrial ISG17 mRNA and a related mRNA are induced by interferon-tau and localized to glandular epithelial and stromal cells from pregnant cows
The objectives of the present experiments were to examine induction of ISG17 and a related 2.5 kb mRNA in response to IFN-τ and pregnancy using Northern blotting procedures, and to determine cell types in the endometrium that expressedISG17 mRNA usingin situ hybridization.
Expression of the interferon tau inducible ubiquitin cross-reactive protein in the ovine uterus.
- G. Johnson, T. Spencer, T. R. Hansen, K. Austin, R. Burghardt, F. Bazer
- BiologyBiology of reproduction
- 1 July 1999
These results are the first to describe temporal and spatial alterations in the cellular localization of UCRP in the ruminant uterus.
Cloning of interferon-stimulated gene 17: the promoter and nuclear proteins that regulate transcription.
It is concluded that the bISG17 gene is similar to the hISG15 gene, retains an ISRE that interacts with IRF-1, and is possibly induced initially by the STATs and later by IRf-1 in response to IFN-tau during early pregnancy.
Expression of trophoblastic interferon genes in sheep and cattle.
Although low amounts of oTP-1 mRNA may be present in ovine conceptuses prior to Day 13, massive induction of this mRNA occurs on Day 13 coincident with the initiation of maternal recognition of pregnancy.