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Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.
TLDR
It is demonstrated that two flavin mono-oxygenase family members, FMO1 and FMO3, oxidize trimethylamine (TMA), derived from gut flora metabolism of choline, to TMAO, and it is shown that F MO3 exhibits 10-fold higher specific activity than F MO1. Expand
Pleiotropic roles of bile acids in metabolism.
TLDR
This review covers the roles of specific bile acids, synthetic agonists, and their cognate receptors in controlling these diverse functions, as well as their current use in treating human diseases. Expand
MicroRNA-144 Regulates Hepatic ATP Binding Cassette Transporter A1 and Plasma High-Density Lipoprotein After Activation of the Nuclear Receptor Farnesoid X Receptor
TLDR
It is shown that activation of the nuclear receptor FXR in vivo increases hepatic levels of miR-144, which in turn lowers hepatic ABCA1 and plasma HDL levels, which together regulate plasma HDL-cholesterol. Expand
Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP
TLDR
It is reported that RNF145, a previously uncharacterized ER membrane ubiquitin ligase, participates in crosstalk between these critical signaling pathways between SREBPs and LXRs, defining an additional mechanism linking hepatic sterol levels to the reciprocal actions of the SREBP-2 and LXR pathways. Expand
Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females
TLDR
The findings indicate the retention of dysfunctional mitochondria in MERKO muscle and implicate ERα in the preservation of mitochondrial health and insulin sensitivity as a defense against metabolic disease in women. Expand
NOTCH1 is a mechanosensor in adult arteries
TLDR
It is proposed that NOTCH1 is atheroprotective and acts as a mechanosensor in adult arteries, where it ensures junctional integrity through modulation of calcium signalling and limits atherosclerosis. Expand
MAFG is a transcriptional repressor of bile acid synthesis and metabolism.
TLDR
This work identifies MafG as an FXR target gene and shows that hepatic MAFG overexpression represses genes of the bile Acid synthetic pathway and modifies the biliary bile acid composition. Expand
Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity.
TLDR
It is proposed that FXR plays a role in hepatic xenobiotic metabolism and, when activated, provides hepatoprotection against toxins such as APAP. Expand
RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism.
TLDR
The ZFP36L1-dependent regulation of bile acid metabolism is an important metabolic contributor to obesity and hepatosteatosis and it is found that mice lacking hepatic ZFP 36L1 were protected from diet-induced obesity and steatosis. Expand
The Nuclear Receptor FXR Uncouples the Actions of miR-33 From SREBP-2
TLDR
It is demonstrated that the activation of FXR uncouples the expression of nuclear SREBP-2 and miR-33, and the regulation of their respective target genes, and it is concluded that the FXR agonist-dependent increase in miR -33 requires transcription of the Srebp-2 gene. Expand
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