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- Publications
- Influence
SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells
- Marcia C Haigis, R. Mostoslavsky, +12 authors L. Guarente
- Biology, Medicine
- Cell
- 8 September 2006
Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, flies, and worms. Mammals have seven Sir2 homologs (SIRT1-7). We show that SIRT4 is a mitochondrial enzyme that… Expand
Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction
Caloric restriction (CR) extends the life span and health span of a variety of species and slows the progression of age-related hearing loss (AHL), a common age-related disorder associated with… Expand
Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging
Mutations in mitochondrial DNA (mtDNA) accumulate in tissues of mammalian species and have been hypothesized to contribute to aging. We show that mice expressing a proofreading-deficient version of… Expand
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over
- S. M. Baker, A. Plug, +9 authors R. Liskay
- Biology, Medicine
- Nature Genetics
- 1 July 1996
Mice that are deficient in either the Pms2 or Msh2 DNA mismatch repair genes have microsatellite instability and a predisposition to tumours. Interestingly, Pms2–deficient males display sterility… Expand
Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations
- Hsiuchen Chen, M. Vermulst, +4 authors D. Chan
- Biology, Medicine
- Cell
- 16 April 2010
Mitochondria are highly mobile and dynamic organelles that continually fuse and divide. These processes allow mitochondria to exchange contents, including mitochondrial DNA (mtDNA). Here we examine… Expand
Gene-expression profile of the ageing brain in mice
- Cheol-Koo Lee, R. Weindruch, T. Prolla
- Biology, Medicine
- Nature Genetics
- 1 July 2000
Ageing of the brain leads to impairments in cognitive and motor skills, and is the major risk factor for several common neurological disorders such as Alzheimer disease (AD) and Parkinson disease… Expand
Gene expression profile of aging and its retardation by caloric restriction.
- C. K. Lee, R. Klopp, R. Weindruch, T. Prolla
- Biology, Medicine
- Science
- 27 August 1999
The gene expression profile of the aging process was analyzed in skeletal muscle of mice. Use of high-density oligonucleotide arrays representing 6347 genes revealed that aging resulted in a… Expand
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
- Alexander S. Hebert, Kristin E Dittenhafer-Reed, +14 authors Joshua J. Coon
- Biology, Medicine
- Molecular cell
- 10 January 2013
Calorie restriction (CR) extends life span in diverse species. Mitochondria play a key role in CR adaptation; however, the molecular details remain elusive. We developed and applied a quantitative… Expand
SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
- Philipp Oberdoerffer, Shaday Michán, +15 authors D. Sinclair
- Biology, Medicine
- Cell
- 28 November 2008
Genomic instability and alterations in gene expression are hallmarks of eukaryotic aging. The yeast histone deacetylase Sir2 silences transcription and stabilizes repetitive DNA, but during aging or… Expand
A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice
Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old… Expand