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Natural products reveal cancer cell dependence on oxysterol-binding proteins.
- Anthony W. G. Burgett, T. Poulsen, M. Shair
- Biology, ChemistryNature Chemical Biology
- 1 September 2011
The ORPphilins are powerful probes of OSBP and ORP4L that will be useful in uncovering their cellular functions and their roles in human diseases.
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
NRF2 agonists 4-OI and DMF induce a distinct IFN-independent antiviral program that is broadly effective in limiting virus replication and in suppressing the pro-inflammatory responses of human pathogenic viruses, including SARS-CoV2.
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
Nrf2 activation decreases STING expression and responsiveness to STING agonists while increasing susceptibility to infection with DNA viruses, and a link between metabolic reprogramming and antiviral cytosolic DNA sensing in human cells is suggested.
Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle*
- H. Feinberg, N. Rambaruth, K. Drickamer
- Biology, ChemistryJournal of Biological Chemistry
- 19 August 2016
Structural and mutagenesis analysis provides evidence for interaction of the hydrophobic substituents with multiple different portions of the surface of mincle and confirms the presence of three Ca2+-binding sites.
Catalytic asymmetric Friedel-Crafts alkylation reactions--copper showed the way.
Alkylation with Activated Alkenes and Carbonyl Compounds in Copper Complexes and Other Metal Complexes: The Incubation Period 2904-2904 3.2.1.
Ketone Body Acetoacetate Buffers Methylglyoxal via a Non-enzymatic Conversion during Diabetic and Dietary Ketosis.
Ester coupling reactions--an enduring challenge in the chemical synthesis of bioactive natural products.
- Michail Tsakos, Eva S. Schaffert, Lise L. Clement, Nikolaj L. Villadsen, T. Poulsen
- ChemistryNatural product reports (Print)
- 25 March 2015
This review investigates the use of complex ester fragment couplings within natural product total synthesis campaigns and presents and discusses a collection of successful examples from the literature.
Enantioselective organocatalytic allylic amination.
- T. Poulsen, Carlos Alemparte, K. Jørgensen
- Chemistry, BiologyJournal of the American Chemical Society
- 2 August 2005
Using a commercially available organocatalyst, a direct highly enantioselective allylic electrophilic functionalization of alkylidene cyanoacetates and malononitriles with azodicarboxylates is demonstrated.
Organocatalytic Asymmetric Direct a-Alkynylation of Cyclic -Ketoesters.
It is demonstrated that activated β-halo-alkynes undergo nucleophilic acetylenic substitution catalyzed by chiral phase-transfer compounds to afford the alkynylated products in high yields and excellent enantioselectivities.
A Catalytic Oxidative Quinone Heterofunctionalization Method: Synthesis of Strongylophorine-26.
- Wanwan Yu, Per Hjerrild, K. M. Jacobsen, Henriette N Tobiesen, Line Clemmensen, T. Poulsen
- ChemistryAngewandte Chemie
- 2 July 2018
Preliminary mechanistic observations and the first synthesis of the cytotoxic natural product strongylophorine-26 is presented and it is shown that Co(OAc)2 and Mn3 ⋅2 H2 O act as powerful catalysts for oxidative p-quinone functionalization with a collection of O, N, and S’nucleophiles, using oxygen as the terminal oxidant.