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Doublecortin maintains bipolar shape and nuclear translocation during migration in the adult forebrain
The ability of the mature mammalian nervous system to continually produce neuronal precursors is of considerable importance, as manipulation of this process might one day permit the replacement ofExpand
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Identification of a cellular node for motor control pathways
The rich behavioral repertoire of animals is encoded in the CNS as a set of motorneuron activation patterns, also called 'motor synergies'. However, the neurons that orchestrate these motor programsExpand
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Phase II trial of weekly bortezomib in combination with rituximab in untreated patients with Waldenström Macroglobulinemia
This study aimed to determine the activity and safety of weekly bortezomib and rituximab in patients with untreated Waldenström Macroglobulinemia (WM). Patients with no prior therapy and symptomaticExpand
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Decreased neurofilament gene expression is an index of selective axonal hypotrophy in ageing.
Axonal atrophy may reflect earlier and more reversible events in neurodegeneration and ageing than somatic atrophy. Innervation density by sympathetic fibres from the rat superior cervical ganglionExpand
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Weekly bortezomib in combination with temsirolimus in relapsed or relapsed and refractory multiple myeloma: a multicentre, phase 1/2, open-label, dose-escalation study.
BACKGROUND Multiple myeloma is the second most prevalent haematological malignancy and is incurable. Our aim was to assess the response and safety of the combination of temsirolimus (an mTORExpand
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Microscopy ambient ionization top-down mass spectrometry reveals developmental patterning
Significance To improve targeted molecular characterization of biological samples, we have interfaced a light microscope with ambient ionization MS to perform microscopy-guided targeted massExpand
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Auto-HSCT induces sustained responses in severe systemic sclerosis patients failing pulse cyclophosphamide
Auto-HSCT induces sustained responses in severe systemic sclerosis patients failing pulse cyclophosphamide
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Nmf9 Encodes a Highly Conserved Protein Important to Neurological Function in Mice and Flies
Many protein-coding genes identified by genome sequencing remain without functional annotation or biological context. Here we define a novel protein-coding gene, Nmf9, based on a forward geneticExpand
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A Multicenter Phase II Study of Single-Agent Enzastaurin in Previously Treated Waldenström Macroglobulinemia
Purpose: Enzastaurin is a serine/threonine kinase inhibitor that showed antiangiogenic, antiproliferative, and proapoptotic properties in vitro and antitumor activity in vivo in a xenograftExpand
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Krox-26 is a Novel C 2 H 2 Zinc Finger Transcription Factor Expressed in Developing Dental and Osteogenic Tissues
The development of teeth through epithelial-mesenchymal interactions is mediated on a molecular level by a network of secreted growth factors and responsive transcription factors. Although zincExpand
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