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Nonlinear model predictive control of glucose concentration in subjects with type 1 diabetes.
A nonlinear model predictive controller has been developed to maintain normoglycemia in subjects with type 1 diabetes during fasting conditions such as during overnight fast. The controller employs aExpand
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Adipose tissue, inflammation and cardiovascular disease.
Obesity has become a very frequent condition with important consequences for the health of affected individuals. Current evidence shows that the excess of adipose tissue as observed in obesity isExpand
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Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome.
OBJECTIVES Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances, in particular from insulin resistance. Accumulating evidence suggests that vitamin D deficiencyExpand
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Efficacy and Safety of Degludec versus Glargine in Type 2 Diabetes
BACKGROUND Degludec is an ultralong‐acting, once‐daily basal insulin that is approved for use in adults, adolescents, and children with diabetes. Previous open‐label studies have shown lowerExpand
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Insulin kinetics in type-1 diabetes: continuous and bolus delivery of rapid acting insulin
We investigated insulin lispro kinetics with bolus and continuous subcutaneous insulin infusion (CSII) modes of insulin delivery. Seven subjects with type-1 diabetes treated by CSII with insulinExpand
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Vitamin D and Immune Function
Vitamin D metabolizing enzymes and vitamin D receptors are present in many cell types including various immune cells such as antigen-presenting-cells, T cells, B cells and monocytes. In vitro dataExpand
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Vitamin D-associated polymorphisms are related to insulin resistance and vitamin D deficiency in polycystic ovary syndrome.
INTRODUCTION Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances including insulin resistance (IR), which might be related to vitamin D metabolism. We aimed toExpand
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Regulation of autophagy by cytosolic acetyl-coenzyme A.
Acetyl-coenzyme A (AcCoA) is a major integrator of the nutritional status at the crossroads of fat, sugar, and protein catabolism. Here we show that nutrient starvation causes rapid depletion ofExpand
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Vitamin D, cardiovascular disease and mortality
A poor vitamin D status, i.e. low serum levels of 25‐hydroxyvitamin D [25(OH)D], is common in the general population. This finding is of concern not only because of the classic vitamin D effects onExpand
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Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial.
IMPORTANCE Low vitamin D status is linked to increased mortality and morbidity in patients who are critically ill. It is unknown if this association is causal. OBJECTIVE To investigate whether aExpand
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