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Enteric Dopaminergic Neurons: Definition, Developmental Lineage, and Effects of Extrinsic Denervation
It is reported that transcripts encoding tyrosine hydroxylase (TH) and the DA transporter (DAT) are present in the murine bowel and concluded that the enteric nervous system contains intrinsic dopaminergic neurons that arise from a mash-1-independent lineage of noncatecholaminergic precursors. Expand
Distinct subpopulations of enteric neuronal progenitors defined by time of development, sympathoadrenal lineage markers and Mash-1-dependence.
Three independent lines of evidence are presented that suggest that enteric neurons arise from at least two lineages, only one of which expresses markers in common with sympathoadrenal cells, which suggest thatEnteric neurons are derived from at at leastTwo progenitor lineages. Expand
Time of origin of neurons in the murine enteric nervous system: Sequence in relation to phenotype
It is shown that it is possible to add neurons to the enteric plexuses even after the neural circuits on which the bowel depends have become functional, consistent with the idea that early developing neurons could affect the development of enteric neural precursors. Expand
Bone Morphogenetic Protein-2 and -4 Limit the Number of Enteric Neurons But Promote Development of a TrkC-Expressing Neurotrophin-3-Dependent Subset
BMP-2 and/or BMP-4 thus limit the size of the ENS but promote the development of specific subsets of enteric neurons, including those that express TrkC, when applied to immunopurified E12 ENS precursors. Expand
Neurotrophin-3 Is Required for the Survival–Differentiation of Subsets of Developing Enteric Neurons
The observations indicate that NT-3 is required for the normal development of the ENS, and a neuropoietic cytokine (CNTF) interacted withNT-3 in vitro, and if applied sequentially, compensated for NT- 3 withdrawal. Expand
In preparations containing portions of the left atrium and valve leaflet, the excitation wave spreads into the leaflet after electrical stimulation of the atrial muscle, suggesting that the accompanying contractile event may occur in situ before the initiation of systole. Expand
Accumulation of components of basal laminae: association with the failure of neural crest cells to colonize the presumptive aganglionic bowel of ls/ls mutant mice.
Observations indicate that there is an accumulation of extracellular matrix material, including components of basal laminae, that precedes the formation of enteric ganglia, is in the path through which enteric neural precursors from the crest would have to migrate, and is limited to the aganglionic and hypoganglionics ls/ls bowel. Expand
Effects of left atrial enlargement on atrial transmembrane potentials and structure in dogs with mitral valve fibrosis.
The structural studies showed that the left atrium of the dogs in Groups I and II had a reduced number of muscle cell layers spanning the wall with an unusually large amount of connective tissue between greatly hypertrophied cells. Expand
The Relationship of Human Atrial Cellular Electrophysiology to Clinical Function and Ultrastructure
The likelihood of occurrence of arrhythmias can be predicted using the analytic method described and the relationship between hemodynamic anomalies and resultant changes in both human atrial fiber structure and electrical function is emphasized. Expand
Bone morphogenetic protein regulation of enteric neuronal phenotypic diversity: Relationship to timing of cell cycle exit
The effects of bone morphogenetic protein (BMP) signaling on enteric neuron development were examined in transgenic mice overexpressing either the BMP inhibitor, noggin, or BMP4 under control of theExpand