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Mechanism of Disruption of the Amt-GlnK Complex by PII-Mediated Sensing of 2-Oxoglutarate
GlnK proteins regulate the active uptake of ammonium by Amt transport proteins by inserting their regulatory T-loops into the transport channels of the Amt trimer and physically blocking substrateExpand
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Signaling ammonium across membranes through an ammonium sensor histidine kinase
Sensing and uptake of external ammonium is essential for anaerobic ammonium-oxidizing (anammox) bacteria, and is typically the domain of the ubiquitous Amt/Rh ammonium transporters. Here, we reportExpand
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Insights into the Bioactivity of Mensacarcin and Epoxide Formation by MsnO8
Mensacarcin, a potential antitumour drug, is produced by Streptomyces bottropensis. The structure consists of a three‐membered ring system with many oxygen atoms. Of vital importance in this contextExpand
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Regulation of Ammonium Transport Proteins
Ammonium, the most reduced form of nitrogen is a primary nutrient for several organisms (archea, bacteria, fungi and plants) and its uptake from the environment is accomplished by dedicated AmmoniumExpand
Crystal Structure of apo-MsnO8