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Red blood cell distribution width and mortality risk in a community-based prospective cohort.
BACKGROUND Red blood cell distribution width (RDW), an automated measure of red blood cell size heterogeneity (eg, anisocytosis) that is largely overlooked, is a newly recognized risk marker inExpand
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Serum Total Bilirubin Level and Prevalent Lower-Extremity Peripheral Arterial Disease: National Health and Nutrition Examination Survey (NHANES) 1999 to 2004
Background—Bilirubin, with recently recognized antioxidant and antiinflammatory activity, has emerged as a candidate for atheroprotection. We hypothesized that higher levels of bilirubin would reduceExpand
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Serum total bilirubin level, prevalent stroke, and stroke outcomes: NHANES 1999-2004.
BACKGROUND Bilirubin inhibits experimental atherosclerosis, is inversely associated with carotid plaque burden, and confers neuroprotection in experimental stroke. Clinical data addressing theExpand
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Uric Acid and the Development of Hypertension: The Normative Aging Study
Experimental evidence supports a causative role for uric acid in the pathogenesis of hypertension. Prospective studies have variably adjusted for relevant confounders and have been of relativelyExpand
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Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism
Mass spectrometry with stable isotope labels has been seminal in discovering the dynamic state of living matter, but is limited to bulk tissues or cells. We developed multi-isotope imaging massExpand
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Smoking, Metalloproteinases, and Vascular Disease
Smoking causes up to 11% of total global cardiovascular deaths. Smoking has numerous effects that may promote atherosclerosis through vascular inflammation and oxidative stress, but the pathogenesisExpand
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Insulin induces renal vasodilation, increases plasma renin activity, and sensitizes the renal vasculature to angiotensin receptor blockade in healthy subjects.
Insulin stimulates the renin-angiotensin system and induces renal vasodilation. The relationship between these opposing influences of insulin on renal vascular tone has not been explored. AExpand
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Uric acid and the state of the intrarenal renin-angiotensin system in humans.
BACKGROUND Experimental hyperuricemia is marked by an activated intrarenal renin-angiotensin system (RAS). The renal vascular response to exogenous angiotensin II (Ang II) provides an indirectExpand
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Cadmium exposure in association with history of stroke and heart failure.
BACKGROUND It is unclear whether environmental cadmium exposure is associated with cardiovascular disease, although recent data suggest associations with myocardial infarction and peripheral arterialExpand
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Body mass index predicts aldosterone production in normotensive adults on a high-salt diet.
CONTEXT The mechanisms underlying obesity-mediated cardiovascular disease are not fully understood. Aldosterone and insulin resistance both are associated with obesity and cardiovascular disease. Expand
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