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Role of quinones in toxicology.
TLDR
The evidence strongly suggests that the numerous mechanisms of quinone toxicity can be correlated with the known pathology of the parent compound(s), including benzene, polycyclic aromatic hydrocarbons, estrogens, and catecholamines. Expand
Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer.
TLDR
Enhanced intracellular conversion of adrenal androgens to testosterone and dihydrotestosterone is a mechanism by which prostate cancer cells adapt to androgen deprivation and suggest new therapeutic targets. Expand
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease.
TLDR
Nrf2 activity is tightly controlled via CRLKeap1 and SCFβ-TrCP by oxidative stress and energy-based signals, allowing it to mediate adaptive responses that restore redox homeostasis and modulate intermediary metabolism. Expand
Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1–AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of
TLDR
The kinetic parameters, steroid substrate specificity and identities of reaction products were determined for four homogeneous recombinant human 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) isoforms of the aldo-keto reductase (AKR) superfamily and the functional plasticity of these isoforms highlights their ability to modulate the levels of active androgens, oestrogens and progestins. Expand
Comparative anatomy of the aldo-keto reductase superfamily.
TLDR
It is proposed that the aldo-keto reductase superfamily may represent an example of divergent evolution from an ancestral multifunctional oxidoreductase and an examples of convergent evolution to the same active-site constellation as the short-chain dehydrogenase/reductasesuperfamily. Expand
Aldo-keto reductases and bioactivation/detoxication.
  • Yi Jin, T. Penning
  • Chemistry, Medicine
  • Annual review of pharmacology and toxicology
  • 8 January 2007
TLDR
Aldo-keto reductases are stress-regulated genes and play a central role in the cellular response to osmotic, electrophilic, and oxidative stress. Expand
Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer
TLDR
The mechanisms underlying the lethal pairing of AR deregulation and aberrant androgen synthesis in prostate cancer progression will be discussed. Expand
Resveratrol is a Peroxidase-mediated Inactivator of COX-1 but Not COX-2
TLDR
It is proposed that resveratrol inactivates COX-1 by a “hit-and-run” mechanism, and offers a basis for the design of selective COx-1 inactivators that work through a mechanism-based event at the peroxidase active site. Expand
Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and
TLDR
The kinetic parameters, steroid substrate specificity and identities of reaction products were determined for four homogeneous recombinant human 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) isoforms of the aldo-keto reductase (AKR) superfamily and their ability to modulate the levels of active androgens, oestrogens and progestins is highlighted. Expand
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