Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging
This work introduces optical frequency domain imaging (OFDI) as an intravital microscopy that circumvents the technical limitations of multiphoton microscopy and provides unprecedented access to previously unexplored, crucial aspects of tissue biology.
Pathology: Cancer cells compress intratumour vessels
- T. Padera, B. Stoll, Jessica B. Tooredman, Diane E. Capen, E. Tomaso, R. Jain
- Biology, MedicineNature
- 19 February 2004
Evidence that proliferating cancer cells cause intratumour vessels to compress and collapse is provided to reduce this compressive mechanical force and opening vessels, cytotoxic cancer treatments have the potential to increase blood perfusion, thereby improving drug delivery.
LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.
It is demonstrated that lymphatics are abundant in cirrhosis by combining LYVE-1 and Prox 1 (a transcription factor) immunohistochemistry and proposed a novel approach to identify lymphatics in human and murine liver.
Hearing improvement after bevacizumab in patients with neurofibromatosis type 2.
- S. Plotkin, A. Stemmer-Rachamimov, E. di Tomaso
- MedicineNew England Journal of Medicine
- 10 December 2009
VEGF blockade with bevacizumab improved hearing in some, but not all, patients with neurofibromatosis type 2 and was associated with a reduction in the volume of most growing vestibular schwannomas.
Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications.
It is indicated that VEGF-C facilitates lymphatic metastasis by increasing the delivery of cancer cells to lymph nodes and therapies directed against VEGf-C/VEGFR-3 signaling target the initial steps of lymphatics metastasis.
Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics
Functional lymphatics associated with mouse tumors expressing normal or elevated levels of vascular endothelial growth factor–C (VEGF-C) are examined to suggest that the functional lymphatics in the tumor margin alone are sufficient for lymphatic metastasis and should be targeted therapeutically.
Solid stress and elastic energy as measures of tumour mechanopathology
Two-dimensional spatial mappings of solid stress and the resulting elastic energy in excised or in situ tumours with arbitrary shapes and wide size ranges can be obtained via three distinct and quantitative techniques that rely on the measurement of tissue displacement after disruption of the confining structures.
Impaired lymphatic contraction associated with immunosuppression
The suppression of lymphatic function by the CD11b+Gr-1+ cells is suggested as a potential mechanism of self-protection from autoreactive responses during on-going inflammation and suggests that other diseases such as cancer and infection may also mediate lymphatic contraction and thus immune response.
Local imbalance of proangiogenic and antiangiogenic factors: a potential mechanism of focal necrosis and dormancy in tumors.
A mathematical framework that describes production, diffusion, and degradation of factors in tumor and host tissue and their effect on angiogenesis at local and distal sites is presented and suggests generally that diffusible factors produced by tumors can stimulate responses in adjacent host tissue, preparing it for further tumor invasion.
Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression.
It is demonstrated that pharmacological VE-PTP inhibition can normalize the structure and function of tumor vessels through Tie-2 activation, which delays tumor growth, slows metastatic progression, and enhances response to concomitant cytotoxic treatments.