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Formation of core-shell type biodegradable polymeric micelles from amphiphilic poly(aspartic acid)-block-polylactide diblock copolymer.
Poly(aspartic acid)-block-polylactide diblock copolymers (PAsp-b-PLAs) having both hydrophilic and hydrophobic segments of various lengths were synthesized. These PAsp-b-PLA diblock copolymers formed… Expand
Synthesis and antitumor activity of conjugates of poly(α-malic acid) and 5-fluorouracils bound via ester, amide or carbamoyl bonds
Abstract Since poly(malic acid) is a biodegradable and bioabsorbable lactic acid-type polyester having pendent modifiable carboxylic acid groups, it is of interest as a polymeric carrier of drugs. In… Expand
Synthesis of branched poly(lactide) using polyglycidol and thermal, mechanical properties of its solution-cast film
Abstract Branched poly(lactide)(PLA)s with various lengths of graft chain were synthesized by ring-opening polymerization of l - or d -lactide ( l - or d -LA) in bulk using polyglycidol as a… Expand
Synthesis and Cytotoxic Activity of Macromolecular Prodrug of Cisplatin Using Poly(ethylene glycol) with Galactose Residues or Antennary Galactose Units
To provide a macromolecular prodrug with recognition ability for hepatoma cells, we synthesized new conjugates of cisplatin (CDDP) and poly(ethylene glycol) (PEG) with galactose residues or antennary… Expand
Preparation and Characterization of Polypseudorotaxanes Based on Biodegradable Poly(l-lactide)/Poly(ethylene glycol) Triblock Copolymers
A variation of A−B−A-type triblock copolymers consisting of poly(l-lactide) (PLLA) and poly(ethylene glycol) (PEG) was synthesized and examined for complexation with α-cyclodextrins (α-CDs). Although… Expand
Release Behavior of 5-Fluorouracil from Chitosan-Gel Nanospheres Immobilizing 5-Fluorouracil Coated with Polysaccharides and Their Cell Specific Cytotoxicity
Abstract Small-sized chitosan-gel nanospheres, CNSs (average diameter 250 nm), containing 5-fluorouracil (5FU) or immobilizing 5FU derivatives (aminopentyl-carbamoyl-5FU or… Expand
Possibility of application of quaternary chitosan having pendant galactose residues as gene delivery tool
Since chitosan is a cationic natural polysaccharide having the formation ability of a polyelectrolyte complex with DNA, it is expected to be used as a carrier of DNA in gene delivery systems. So, in… Expand
Aggregation phenomenon of PEG-grafted chitosan in aqueous solution
Chitosan (deacetylated chitin), which is a naturally occurring polysaccharide having primary amino groups, is known to be insoluble in water because of its strong intermolecular hydrogen bonds. We… Expand
Release behaviour of 5-fluorouracil from chitosan-gel microspheres immobilizing 5-fluorouracil derivative coated with polysaccharides and their cell specific recognition.
- Y. Ohya, T. Takei, H. Kobayashi, T. Ouchi
- Materials Science, Medicine
- Journal of microencapsulation
In order to provide a device releasing drugs in a controlled manner and having targetability to specific organs or cells, chitosan-gel microspheres, CMS, crosslinked with glutaraldehyde, immobilizing… Expand
Biodegradable shape-memory polymers exhibiting sharp thermal transitions and controlled drug release.
Biodegradable shape-memory polymer networks prepared by cross-linking star shape branched oligo(ε-caprolactone) (bOCL) with hexamethylene diisocyanate are introduced. The thermal and mechanical… Expand