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Formation of core-shell type biodegradable polymeric micelles from amphiphilic poly(aspartic acid)-block-polylactide diblock copolymer.
Poly(aspartic acid)-block-polylactide diblock copolymers (PAsp-b-PLAs) having both hydrophilic and hydrophobic segments of various lengths were synthesized. These PAsp-b-PLA diblock copolymers formedExpand
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Synthesis and antitumor activity of conjugates of poly(α-malic acid) and 5-fluorouracils bound via ester, amide or carbamoyl bonds
Abstract Since poly(malic acid) is a biodegradable and bioabsorbable lactic acid-type polyester having pendent modifiable carboxylic acid groups, it is of interest as a polymeric carrier of drugs. InExpand
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Synthesis of branched poly(lactide) using polyglycidol and thermal, mechanical properties of its solution-cast film
Abstract Branched poly(lactide)(PLA)s with various lengths of graft chain were synthesized by ring-opening polymerization of l - or d -lactide ( l - or d -LA) in bulk using polyglycidol as aExpand
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Synthesis and Cytotoxic Activity of Macromolecular Prodrug of Cisplatin Using Poly(ethylene glycol) with Galactose Residues or Antennary Galactose Units
To provide a macromolecular prodrug with recognition ability for hepatoma cells, we synthesized new conjugates of cisplatin (CDDP) and poly(ethylene glycol) (PEG) with galactose residues or antennaryExpand
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Preparation and Characterization of Polypseudorotaxanes Based on Biodegradable Poly(l-lactide)/Poly(ethylene glycol) Triblock Copolymers
A variation of A−B−A-type triblock copolymers consisting of poly(l-lactide) (PLLA) and poly(ethylene glycol) (PEG) was synthesized and examined for complexation with α-cyclodextrins (α-CDs). AlthoughExpand
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Release Behavior of 5-Fluorouracil from Chitosan-Gel Nanospheres Immobilizing 5-Fluorouracil Coated with Polysaccharides and Their Cell Specific Cytotoxicity
Abstract Small-sized chitosan-gel nanospheres, CNSs (average diameter 250 nm), containing 5-fluorouracil (5FU) or immobilizing 5FU derivatives (aminopentyl-carbamoyl-5FU orExpand
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Possibility of application of quaternary chitosan having pendant galactose residues as gene delivery tool
Since chitosan is a cationic natural polysaccharide having the formation ability of a polyelectrolyte complex with DNA, it is expected to be used as a carrier of DNA in gene delivery systems. So, inExpand
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Aggregation phenomenon of PEG-grafted chitosan in aqueous solution
Chitosan (deacetylated chitin), which is a naturally occurring polysaccharide having primary amino groups, is known to be insoluble in water because of its strong intermolecular hydrogen bonds. WeExpand
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Release behaviour of 5-fluorouracil from chitosan-gel microspheres immobilizing 5-fluorouracil derivative coated with polysaccharides and their cell specific recognition.
In order to provide a device releasing drugs in a controlled manner and having targetability to specific organs or cells, chitosan-gel microspheres, CMS, crosslinked with glutaraldehyde, immobilizingExpand
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Biodegradable shape-memory polymers exhibiting sharp thermal transitions and controlled drug release.
Biodegradable shape-memory polymer networks prepared by cross-linking star shape branched oligo(ε-caprolactone) (bOCL) with hexamethylene diisocyanate are introduced. The thermal and mechanicalExpand
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