• Publications
  • Influence
Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice
TLDR
These findings show that genetic targeting can be used to ablate scar-forming astrocytes and demonstrate roles for astroCytes in regulating leukocyte trafficking, repairing the BBB, protecting neurons, and restricting nerve fiber growth after injury in the adult central nervous system.
A new method for the rapid and long term growth of human neural precursor cells
TLDR
This simple and novel culture method allows the rapid expansion of large numbers of non-transformed human neural precursor cells which may be of use in drug discovery, ex vivo gene therapy and clinical neural transplantation.
Human Neural Precursor Cells Express Low Levels of Telomerase in Vitro and Show Diminishing Cell Proliferation with Extensive Axonal Outgrowth following Transplantation
TLDR
It is shown that human neural precursor cells express very low levels of telomerase at early passages, but that this decreases to undetectable levels at later passages, which may provide the ideal basis for the repair of other lesions of the CNS where extensive axonal outgrowth is required.
Regional specification of rodent and human neurospheres.
TLDR
The data show that rat and human neurospheres have unique characteristics with regard to growth and differentiation, and that the majority of precursor cells within neuro Spheres are regionally specified to generate set numbers of neurons.
Human Neural Stem Cells: Isolation, Expansion and Transplantation
TLDR
This review summarises this fascinating and growing field of neurobiology, with a particular focus on human tissues, and discusses the possibility of cell replacement therapy for a wide range of neurological disorders.
Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury
TLDR
Dilmapimod was well tolerated, with no clinically relevant safety findings, and p38 MAPK inhibitors merit further evaluation for neuropathic pain in larger clinical trials, particularly for clinically meaningful analgesic effect size.
Neurospheres modified to produce glial cell line‐derived neurotrophic factor increase the survival of transplanted dopamine neurons
TLDR
It is shown that rodent neural precursor cells isolated and expanded in culture as neurospheres (NS) can be genetically modified to express green fluorescent protein (GFP) or to release GDNF using lentiviral constructs and that sustained levels of neural precursor‐mediated transgene expression can be achieved following transplantation in the future.
Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects.
TLDR
The model-based approach maximized analysis power by integrating all biomarker data and revealed mechanistic insight into the pharmacology of P2X7 modulation by GSK1482160, which led to the discontinuation of the development of this compound.
Requirement for Neurogenesis to Proceed through the Division of Neuronal Progenitors following Differentiation of Epidermal Growth Factor and Fibroblast Growth Factor‐2–Responsive Human Neural Stem
TLDR
The differentiation ofhuman neurospheres provides a useful model of human neurogenesis, and the data presented indicate that it proceeds through the division of committed neuronal progenitor cells rather than directly from the neural stem cell.
Recent advances in stem cell neurobiology.
TLDR
While considerable recent progress has been made in terms of developing new techniques allowing for the long-term culture of human stem cells, the successful clinical application of these cells is presently limited by the lack of suitable markers needed for the identification and selection of cells within proliferating heterogeneous populations of precursor cells.
...
1
2
3
...