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Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion.
TLDR
It is demonstrated that peripheral blood mononuclear cell-derived OCs enhanced growth and survival of primary MM cells as well as MM cell lines more potently than stromal cells, and that OCs protected MM cells from apoptosis induced by serum depletion or doxorubicin.
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Impact of body mass index and visceral adiposity on outcomes in colorectal cancer
Aim:  Obesity and visceral obesity are closely related to the development of colorectal cancer, as well as other metabolic complications. We investigated the prognostic significance of body mass…
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Safety and efficacy of pembrolizumab in combination with S-1 plus oxaliplatin as a first-line treatment in patients with advanced gastric/gastroesophageal junction cancer: Cohort 1 data from the…
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Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer.
TLDR
Analysis of the relations between clinicopathological features and expression of the eight circadian genes in cancer tissue showed that high expression ofThe Bmal1 gene and lowexpression of the Per1 gene correlated with liver metastasis.
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Omentum-preserving gastrectomy for advanced gastric cancer: a propensity-matched retrospective cohort study
TLDR
Omentum-preserving gastrectomy for advanced gastric cancer did not increase the peritoneal relapse rate or affect patient survival compared to conventional Gastrectomy, and the non-inferiority of the omission of omentectomy should be evaluated by a randomized controlled trial.
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The clinicopathological features of colorectal mucinous adenocarcinoma and a therapeutic strategy for the disease
TLDR
This study indentified that mucinous adenocarcinoma was associated with a worse survival compared with non-mucinous in patients with StageIII and IV disease, while survival did not differ significantly in patients diagnosed as Stage0-II disease.
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Surgical outcomes of laparoscopy-assisted gastrectomy versus open gastrectomy for gastric cancer: a case-control study
TLDR
LAG for gastric cancer may be both feasible and safe, however, it will be necessary to conduct a well-designed randomized controlled trial comparing short-term and long-term outcomes between LAG and OG in a larger number of patients.
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Priority of Lymph Node Dissection for Siewert Type II/III Adenocarcinoma of the Esophagogastric Junction
TLDR
Results suggest that the highest priority nodal stations to be dissected were the paracardial and lesser curvature nodes and the nodes at the root of the left gastric artery, regardless of the Siewert subtype, but the subsequent priority was different depending on the subtype.
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Impact of preoperative hand grip strength on morbidity following gastric cancer surgery
TLDR
A low hand grip strength was a significant risk factor for morbidity after gastric cancer surgery, and the importance of the hand gripstrength as a risk factor should be examined in future prospective studies.
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Application of the transorally inserted anvil (OrVil™) after laparoscopy-assisted total gastrectomy
TLDR
LATG using OrVil™ for the treatment of early gastric cancer is a technically feasible surgical procedure with sufficient lymph node dissection, satisfactory early recovery, and acceptable morbidity.
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