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Mechanism of Anticancer Host Response Induced by OK-432, a Streptococcal Preparation, Mediated by Phagocytosis and Toll-Like Receptor 4 Signaling
In in vivo experiments, the anticancer effect of OK-432 was significantly inhibited by suppression of phagocytosis activity by cytochalasin B, and in vitro experiments elucidated the mechanism mediated by phagocytes and TLR4 signaling in the immune effect ofOK-432. Expand
p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.
BACKGROUND & AIMS The tumor suppressor p53 is a primary sensor of stressful stimuli, controlling a number of biologic processes. The aim of our study was to examine the roles of p53 in non-alcoholicExpand
A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells.
Dietary cholesterol aggravates liver fibrosis because free cholesterol accumulates in HSCs, leading to increased TLR4 signaling, down-regulation of bone morphogenetic protein and activin membrane-bound inhibitor, and sensitization of HSC to TGFβ, which might be targeted by antifibrotic therapies. Expand
Expression of Toll-Like Receptor 4 on Dendritic Cells Is Significant for Anticancer Effect of Dendritic Cell-Based Immunotherapy in Combination with an Active Component of OK-432, a Streptococcal
It is suggested that OK-PSA may be a potent adjuvant for local DC therapy, and that DC therapy followed by OK- PSA is able to elicit anticancer activity even in aTLR4-deficient host when TLR4 is expressed only in DCs injected intratumorally. Expand
Mechanism for bone invasion of oral cancer cells mediated by interleukin‐6 in vitro and in vivo
Although interleukin (IL)‐6 accelerates osteoclastic bone resorption, it remains unclear whether IL‐6 may be involved in bone invasion of oral cancer. Expand
Involvement of Toll-like receptor 4 signaling in interferon-gamma production and antitumor effect by streptococcal agent OK-432.
TLR4 and MD-2 may mediate OK-432-induced anticancer immunity and be associated with the in vivo IFN-gamma induction in 19 patients administeredOK-432. Expand
Toll-Like Receptor 4 Mediates the Antitumor Host Response Induced by a 55-Kilodalton Protein Isolated from Aeginetia indica L., a Parasitic Plant
It is suggested that TLR4 mediates antitumor immunity induced by the plant-derived protein AILb-A, which was severely impaired inTLR4-deficient but not TLR2- deficient mice. Expand
Chemical constituents from the Colombian medicinal plant Maytenus laevis.
The methanol extract of the bark of the Colombian medicinal plant Maytenus laevis gave six new compounds and 28 known compounds, and canophyllol demonstrated the most effective induction of the cytokines. Expand
Induction of Th1-type cytokines by lipoteichoic acid-related preparation isolated from OK-432, a penicillin-killed streptococcal agent.
Findings clearly indicated that OK-PSA, an LTA-related molecule, is a main effective component of OK-432, and is a potent inducer of Th1-type cytokines by T cell and natural killer (NK) cell activation mediated by monocytes-derived IL-18, and that it may be a useful immunotherapeutic agent for the patients with malignancies better than original Ok-432. Expand
Cyclobutane dimers from the Colombian medicinal plant Achyrocline bogotensis.
Five cyclobutane dimers, achyrodimers A-E (1-5), along with 11 known compounds were isolated from the methanol extract of the Colombian medicinal plant Achyrocline bogotensis and several of these compounds were screened for cytokine-inducing activity in human peripheral blood mononuclear cells. Expand