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Suppressive effects of 4‐phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress
Results suggest that 4‐PBA suppresses ER stress by directly reducing the amount of misfolded protein, including Pael‐R accumulated in the ER.
A different pathway in the endoplasmic reticulum stress‐induced expression of human HRD1 and SEL1 genes
The results suggest that the ER stress‐induced ERAD gene expressions are mediated by different pathways, which are attributed to the differences in the promoter regions.
HRD1 Levels Increased by Zonisamide Prevented Cell Death and Caspase-3 Activation Caused by Endoplasmic Reticulum Stress in SH-SY5Y Cells
It is shown that low micromolar concentrations of zonisamide prevented cleavage of caspase-3 and cell death in human dopaminergic SH-SY5Y neuroblastoma cells that were subjected to endoplasmic reticulum stress induced by tunicamycin or 6-hydroxydopamine.
Identification and characterization of plant Haspin kinase as a histone H3 threonine kinase
The results indicated that the Haspin kinase is a histone H3 threonine kinase in A. thaliana, and expression and dominant-negative analysis showed that AtHaspin may have a role in mitotic cell division during plant growth.
Meloxicam protects cell damage from 1-methyl-4-phenyl pyridinium toxicity via the phosphatidylinositol 3-kinase/Akt pathway in human dopaminergic neuroblastoma SH-SY5Y cells
Meloxicam may have therapeutic potential in preventing development or delaying progress of PD, and the neuroprotective effect of meloxicam is mediated by the maintenance of cell survival signaling in the PI3K/Akt pathway, but not by COX-2 inhibition.
Different requirement for cytochrome b5 in NADPH-supported O-deethylation of p-nitrophenetole catalyzed by two types of microsomal cytochrome P-450.
  • S. Kuwahara, T. Omura
  • Chemistry, Medicine
    Biochemical and biophysical research…
  • 31 October 1980
The observed effects of cytochrome b 5 on the activities of reconstituted systems and the oxidations of ethylmorphine and aniline by these two types of Cytochrome P-450 did not show significant dependence on cyto Chrome b 5, suggesting that the requirement for cyto chrome b 5 in NADPH-supported drug oxidations depends not only on the species of cy tochrome P -450 catalyzing the reactions, but also on the substrates oxidized.
Meloxicam ameliorates motor dysfunction and dopaminergic neurodegeneration by maintaining Akt-signaling in a mouse Parkinson's disease model
It is suggested that MLX, an oxicam NSAID, attenuated dopaminergic neuronal death in the experimental MPTP-PD model by maintenance of the Akt-signaling and may serve as potential drugs for PD treatment via a novel mechanism of action.
A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin
This study shows that HRD1 was expressed in substantia nigra pars compacta (SNC) dopaminergic neurons and interacted with Pael‐R through theHRD1 proline‐rich region, promoting the ubiquitylation and degradation of Pael'R.
Impact of cytochrome P450 3A5 polymorphism in graft livers on the frequency of acute cellular rejection in living-donor liver transplantation
The target level of tacrolimus may be affected by the CYP3A5*3 genotype of the liver, rather than by that of the small intestine, after postoperative day 14, which may affect the risk of acute cellular rejection after living-donor liver transplantation.
Sodium tauroursodeoxycholate prevents paraquat-induced cell death by suppressing endoplasmic reticulum stress responses in human lung epithelial A549 cells.
It is demonstrated that paraquat changed the expression levels of unfolded protein response-related molecules, resulting in ERS-related cell death in human lung epithelial A549 cells, and treatment with sodium tauroursodeoxycholate (TUDCA), a chemical chaperone, crucially rescued cells from death caused by exposure to paraquats.