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TMC-95A, B, C, and D, novel proteasome inhibitors produced by Apiospora montagnei Sacc. TC 1093. Taxonomy, production, isolation, and biological activities.
TLDR
TMC-95A did not inhibit m-calpain, cathepsin L, and trypsin at 30 microM, suggesting its high selectivity for proteasome, and taxonomy of the producing strain is also described.
Selective Isolation and Distribution of Actinomadura rugatobispora Strains in Soil
TLDR
These results indicated that A. rugatobispora strains were distributed worldwide and were more resistant to 100 μg/ml gentamicin and 20 μg/ML ampicillin than Streptomyces strains, which interfere with the growth of A. Rugatob ispora selectively.
TMC-256A1 and C1, new inhibitors of IL-4 signal transduction produced by Aspergillus niger var niger TC 1629.
TLDR
TMC-256A1 and C1 were found to be new members of the naphthopyrone antibiotics and inhibited the expression of germline C epsilon mRNA in this assay system.
Anicequol, a novel inhibitor for anchorage-independent growth of tumor cells from Penicillium aurantiogriseum Dierckx TP-F0213.
TLDR
A novel inhibitor for anchorage-independent growth of tumor cells was isolated from the culture broth of a fungal strain and inhibition of human colon cancer DLD-1 cells with the IC50 of 1.2 microM was inhibited.
Selective Isolation and Distribution ofSporichthya Strains in Soil
TLDR
A simplified enrichment method in which centrifugation is used for selective isolation of Sporichthya strains from soil is described, finding that S. polymorpha was sensitive to 14 antibiotics, including nalidixic acid, and addition of these antibiotics was not suitable for isolating these strains.
A high-throughput screen for inhibitors of the prolyl isomerase, Pin1, identifies a seaweed polyphenol that reduces adipose cell differentiation
TLDR
The seaweed polyphenol 974B that reduces adipose cell differentiation is discovered from the seaweed, E. kurome, and it is shown that it blocks the differentiation of fibroblasts into adipose cells, suggesting that 974-B could be a lead drug candidate for obesity-related disorders.
Specific PCR assays for the detection of Trichoderma harzianum causing green mold disease during mushroom cultivation
TLDR
A polymerase chain reaction (PCR)-based detection method for Trichoderma harzianum, which causes green mold disease in mushroom cultivation fields and facilities, was readily detectable in contaminated cultures of Lentinula edodes by this method.
Selective isolation of Actinobispora on gellan gum plates
TLDR
A new medium, HVG, containing calcium chloride and gellan gum as a solidifying agent was thus developed based on humic acid - vitamin agar, and a number of Actinobispora strains were successfully isolated on this medium from 14 soil samples, which were collected in Canada, France, Japan, the United Kingdom, and the United States.
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