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Inhibition of inducible nitric oxide synthase prevents LPS-induced acute lung injury in dogs.
Nitric oxide (NO) is produced by inducible NO synthase (iNOS) after LPS stimulation, and reacts with superoxide to form peroxynitrite. We hypothesize that in LPS-induced lung injury, NO generated byExpand
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Expiratory muscle training and sensation of respiratory effort during exercise in normal subjects.
BACKGROUND--The sensation of respiratory effort may increase as expiratory muscles become fatigued during expiratory loading. A study was performed to determine whether expiratory muscle trainingExpand
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Expiratory muscle fatigue in normal subjects.
We examined expiratory muscle fatigue during expiratory resistive loading in 11 normal subjects. Subjects breathed against expiratory resistances at their own breathing frequency and tidal volumeExpand
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Misuse Cases + Assets + Security Goals
We propose a new extension of the misuse case diagram for analyzing and eliciting security requirements with special focus on assets and security goals. Expand
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Acute exposure to cigarette smoke induces airway hyperresponsiveness without airway inflammation in guinea pigs. Dose-response characteristics.
We examined whether acute exposure to a low dose of cigarette smoke causes an increase in airway responsiveness in guinea pigs and whether the changes in airway responsiveness are accompanied byExpand
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Effects of ozone exposure on experimental asthma in guinea pigs sensitized with ovalbumin through the airway.
As ozone (O3) is known to cause airway inflammation and hyperresponsiveness, we examined the effects of O3 exposure (1, 3, or 5 ppm, 2 h) on sensitization and provocation in guinea pigs sensitizedExpand
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Intrapulmonary gas mixing in excised dog lung lobes studied by simultaneous washout of two inert gases.
Abstract To study the role played by stratified inhomogeneity in limiting alveolar gas exchange, simultaneous wash-out of He and SF6 was measured in excised, unperfused lung lobes of small dogs (meanExpand
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Effects and mechanism of fenoterol on fatigued canine diaphragm.
We have studied the effects and mechanism of fenoterol (a beta 2-agonist) on contractility of the fatigued canine diaphragm. Transdiaphragmatic pressure (Pdi) was measured by a pair of balloons, andExpand
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In vivo fatiguing contraction of rat diaphragm produces hydroxyl radicals.
It is suggested that free radical generation is a cause of muscle fatigue from in vitro studies. We examined whether hydroxyl radical would be generated in an in vivo fatiguing contraction of theExpand
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The apparent buffer value of cerebrospinal fluid in acute hypercapnia.
Buffer mechanism of cerebrospinal fluid (CSF) against acute hypercapnia was studied in eighteen dogs. The dynamic response of CSF to a stepwise change of CO2 concentration in inspired gas (room airExpand
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