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Endogenous d‐Serine in Rat Brain: N‐Methyl‐d‐Aspartate Receptor‐Related Distribution and Aging
It is proposed that d‐serine is a novel candidate as an intrinsic ligand for the glycine site in mammalian brain, which is closely correlated with those of the N‐methyl‐d‐aspartate‐type excitatory amino acid receptor. Expand
Anatomical Distribution and Postnatal Changes in Endogenous Free D‐Aspartate and D‐Serine in Rat Brain and Periphery
D‐aspartate could participate in the regulation of these developmental processes of organs during critical periods of morphological and functional maturation of organs, and may be a tenable candidate for an intrinsic ligand for the glycine site. Expand
Determination of free amino acid enantiomers in rat brain and serum by high-performance liquid chromatography after derivatization with N-tert.-butyloxycarbonyl-L-cysteine and o-phthaldialdehyde.
The concurrent determination of free amino acid enantiomers and non-chiral amino acids in rat brain and serum was accomplished by high-performance liquid chromatography with fluorimetric detectionExpand
Free d-aspartate and d-serine in the mammalian brain and periphery
This review deals with the recent advances in the studies of presence of free D-aspartate and D-serine and their metabolic systems in mammals and shall discuss also the NMDA receptor and uptake system of D-amino acids. Expand
Extracellular concentration of endogenous free d-serine in the rat brain as revealed by in vivo microdialysis
The regional variation in the basal overflow of D-serine was proportional to that of its tissue levels which has been shown to closely correlate with the distribution of the N-methyl-D-aspartate type excitatory amino acid receptor. Expand
Widespread distribution of free d‐aspartate in rat periphery
Free d‐aspartate was highest in the adrenal, testis, spleen and pituitary, followed by the thymus, lung, ovary, placenta, pancreas and heart, and below the detection limit in the kidney, liver, brain, muscle and serum. Expand
The role of bestatin-sensitive aminopeptidase, angiotensin converting enzyme and thiorphan-sensitive "enkephalinase" in the potency of enkephalins in the guinea-pig ileum.
Results showed that three distinct enzymes, bestatin-sensitive aminopeptidase(s), angiotensin converting enzyme, and thiorphan-sensitive "enkephalinase", played a critical role in the inactivation of enkephalins. Expand
Stimulus effects of the medial pontine reticular formation and the mesencephalic locomotor region upon medullary reticulospinal neurons in acute decerebrate cats
The results suggest that mPRF stimulation suppresses the activity of the locomotor rhythm generating system at the levels of not only the spinal cord but also the medullary output cells. Expand
Evidence that dynorphin-(1-13) acts as an agonist on opioid kappa-receptors.
The data indicate that dynorphin-(1-13) acts as an endogenous agonist on kappa-receptors, and Mr 2266 was found to be several-fold more effective than naloxone to antagonize the agonist actions of both kappa. Expand