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Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
TLDR
It is suggested that continuous neurogenesis is required for the maintenance and reorganization of the whole interneuron system in the olfactory bulb, the modulation and refinement of the existing neuronal circuits in the dentate gyrus and the normal behaviors involved in hippocampal-dependent memory. Expand
Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation
TLDR
It is demonstrated that Hes1 and Hes5 are essential Notch effectors in regulation of mammalian neuronal differentiation in neural precursor cells prepared from wild‐type, Hes1‐null, Hes5‐null and Hes1-Hes5 double‐null mouse embryos. Expand
Roles of bHLH genes in neural stem cell differentiation.
TLDR
The activator-type and repressor-type bHLH genes regulate each other, allowing only subsets of cells to undergo differentiation while keeping others to stay neural stem cells. Expand
Oscillatory Expression of the bHLH Factor Hes1 Regulated by a Negative Feedback Loop
TLDR
It is shown that serum treatment of cultured cells induces cyclic expression of both mRNA and protein of the Notch effector Hes1, a basic helix-loop-helix (bHLH) factor, with 2-hour periodicity, which may regulate timing in many biological systems. Expand
The Hes gene family: repressors and oscillators that orchestrate embryogenesis
TLDR
This primer describes the pleiotropic roles of Hes genes in some developmental processes and aims to clarify the basic mechanism of how gene networks operate in vertebrate embryogenesis. Expand
Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors
TLDR
It is found that Hes1 expression dynamically oscillates in neural progenitors, and sustained overexpression of Hes1 downregulates expression of proneural genes, Notch ligands, and cell cycle regulators, suggesting that their proper expression depends on Hes1 oscillation. Expand
Temporal regulation of Cre recombinase activity in neural stem cells
TLDR
Transgenic mice that express Cre‐ERT2 in the ventricular zone of the developing nervous system under the control of the nestin promoter and enhancer (Nes‐CreERT2) offer a powerful tool to manipulate neural stem cells genetically at desired time points. Expand
Roles of the Basic Helix-Loop-Helix Genes Hes1 and Hes5 in Expansion of Neural Stem Cells of the Developing Brain*
TLDR
It is found that transient misexpression of the basic helix-loop-helix genes Hes1 and Hes5 keeps embryonal telencephalic cells undifferentiated although they have been shown to induce gliogenesis in the retina. Expand
Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition
TLDR
Hes1-driven Ngn2 and Dll1 oscillations seem to be advantageous for maintenance of a group of cells in an undifferentiated state by mutual activation of Notch signaling. Expand
Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline
TLDR
A novel role for bHLH genes in the process of deciding which cells will have a non-neural versus a neural fate is identified, and it is found that the prospective choroid plexus region initially gives rise to Cajal-Retzius cells, specialized neurons that guide neuronal migration. Expand
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