A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice.
Acute and chronic experimental ulcerative colitis models were produced in mice by providing them with drinking water containing synthetic dextran sulfate sodium. Mice that developed acute colitis…
Promotion of colorectal neoplasia in experimental murine ulcerative colitis.
Repeated mucosal erosion with necrosis and regeneration is critical for the development of colorectal tumours in this experimental colitis system.
A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice
High prevalence of Helicobacter pylori detected by PCR in the oral cavities of periodontitis patients.
Close attention should be given to periodontitis patients who harbor H. pylori in the oral cavity even after eradication of the bacterium from the stomach and duodenum, as well as to patients who harbored Bacteroides forsythus in their oral cavities.
Intestinal microbiota and ulcerative colitis.
Helicobacter pylori infection induces duodenitis and superficial duodenal ulcer in Mongolian gerbils.
Gut Microbiota and Chronic Constipation: A Review and Update
- T. Ohkusa, S. Koido, Yuriko Nishikawa, N. Sato
- Medicine, BiologyFrontiers in Medicine
- 12 February 2019
Evidence indicates that dysbiosis of gut microbiota may contribute to functional constipation and constipation-type irritable bowel syndrome, especially for refractory constipation to conventional therapies.
Dysplasia and carcinoma development in a repeated dextran sulfate sodium‐induced colitis model
- I. Okayasu, M. Yamada, T. Mikami, Tsutomu Yoshida, J. Kanno, T. Ohkusa
- MedicineJournal of Gastroenterology and Hepatology
- 1 October 2002
A dysplasia‐carcinoma sequence in a novel repeated colitis model in mice is documented and an important mechanism underlying the increased risk of colorectal carcinoma development in patients with long‐standing ulcerative colitis is identified.
Oesophageal hypersensitivity in Japanese patients with non‐erosive gastro‐oesophageal reflux diseases
Visceral hypersensitivity plays a major role in the pathogenesis of non‐erosive oesophageal reflux disease (NERD) and is well studied in Japanese patients.
Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative colitis
This study indicates that F varium may be one of the elusive pathogenic factors in UC, and enemas containing organic acid in supernatants of cytotoxic strains caused UC-like lesions in mice.