T. Ohkusa

Publications238
h-index41
Citations7,389
Highly Influential Citations235
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A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice.
Acute and chronic experimental ulcerative colitis models were produced in mice by providing them with drinking water containing synthetic dextran sulfate sodium. Mice that developed acute colitis… Expand
A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice
Acute and chronic experimental ulcerative colitis models were produced in mice by providing them with drinking water containing synthetic dextran sulfate sodium. Mice that developed acute colitis… Expand
Promotion of colorectal neoplasia in experimental murine ulcerative colitis.
TLDR
Repeated mucosal erosion with necrosis and regeneration is critical for the development of colorectal tumours in this experimental colitis system. Expand
High prevalence of Helicobacter pylori detected by PCR in the oral cavities of periodontitis patients.
TLDR
Close attention should be given to periodontitis patients who harbor H. pylori in the oral cavity even after eradication of the bacterium from the stomach and duodenum, as well as to patients who harbored Bacteroides forsythus in their oral cavities. Expand
Dysplasia and carcinoma development in a repeated dextran sulfate sodium‐induced colitis model
TLDR
A dysplasia‐carcinoma sequence in a novel repeated colitis model in mice is documented and an important mechanism underlying the increased risk of colorectal carcinoma development in patients with long‐standing ulcerative colitis is identified. Expand
Oesophageal hypersensitivity in Japanese patients with non‐erosive gastro‐oesophageal reflux diseases
TLDR
Visceral hypersensitivity plays a major role in the pathogenesis of non‐erosive oesophageal reflux disease (NERD) and is well studied in Japanese patients. Expand
Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative colitis
TLDR
This study indicates that F varium may be one of the elusive pathogenic factors in UC, and enemas containing organic acid in supernatants of cytotoxic strains caused UC-like lesions in mice. Expand
Intestinal microbiota and ulcerative colitis.
  • T. Ohkusa, S. Koido
  • Medicine
  • Journal of infection and chemotherapy : official…
  • 1 November 2015
TLDR
This review focuses on the important role that the intestine microbiota plays in maintaining innate immunity in the pathogenesis and etiology of UC and discusses new antibiotic therapies targeting the intestinal microbiota. Expand
Alteration of histological gastritis after cure of Helicobacter pylori infection
Background : It is still disputed whether gastric atrophy or intestinal metaplasia improves after the cure of Helicobacter pylori infection.
Helicobacter pylori infection induces duodenitis and superficial duodenal ulcer in Mongolian gerbils.
TLDR
Induction of duodenal ulcer in an animal model fulfills the requirements of Koch's postulates for establishing a role for H pylori as a causative agent. Expand
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