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ARK5 Is a Tumor Invasion-Associated Factor Downstream of Akt Signaling
ABSTRACT AMP-activated protein kinases (AMPKs) are a class of serine/threonine protein kinases that are activated by an increase in intracellular AMP concentration. They are a sensitive indicator ofExpand
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Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide.
Nitric oxide (NO) regulates production of vascular endothelial growth factor (VEGF) by normal and transformed cells. We demonstrate that NO donors may up-regulate the activity of the human VEGFExpand
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Identification of Hypoxia-inducible Factor 1 Ancillary Sequence and Its Function in Vascular Endothelial Growth Factor Gene Induction by Hypoxia and Nitric Oxide*
Transcription of hypoxia-inducible genes is regulated by hypoxia response elements (HREs) located in either the promoter or enhancer regions. Analysis of these elements reveals the presence of one orExpand
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Identification of a Novel Protein Kinase Mediating Akt Survival Signaling to the ATM Protein*
We identified a novel human AMP-activated protein kinase (AMPK) family member, designated ARK5, encoding 661 amino acids with an estimated molecular mass of 74 kDa. The putative amino acid sequenceExpand
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Remarkable tolerance of tumor cells to nutrient deprivation: possible new biochemical target for cancer therapy.
We hypothesized that the tolerance for nutrient deprivation as well as angiogenesis might be an important factor for tumor progression under hypovascular conditions. When normal human fibroblastsExpand
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IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.
Serine/threonine protein kinase AMP-activated protein kinase (AMPK) is a key metabolic stress-responsive factor that promotes the adaptation of cells to their microenvironment. ElevatedExpand
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Hypoxia induces transcription of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase‐4 gene via hypoxia‐inducible factor‐1α activation
The PFKFB4 gene encodes isoenzyme of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase (PFKFB or PFK‐2/FBPase‐2) which originally was found in the testes. We have studied hypoxic regulation ofExpand
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Establishment and biological characterization of an in vitro human cytomegalovirus latency model.
In an attempt to develop an in vitro human cytomegalovirus (HCMV) latency model system, the growth characteristics of HCMV in a human thyroid papillary carcinoma cell line (TPC-1) were examined. WhenExpand
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ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation
AMPK is a serine/threonine protein kinase family and we recently identified a novel member, ARK5. The activation of ARK5 is triggered by Akt, and ARK5 induces tumor cell survival during nutrientExpand
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Regulation of caspase-6 and FLIP by the AMPK family member ARK5
Colorectal cancer cells are unique in that they escape Fas-mediated cell death in the presence of Fas ligand, and we recently reported that AMP-activated protein kinase-related kinase 5 (ARK5)Expand
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