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Pharmacokinetic drug interactions between ampiroxicam and sulfaphenazole in rats.
The results suggest that SP does not significantly affect the pharmacokinetics of AM and PX in rats, and the Pharmacokinetic drug interaction between both drugs in man may not always be ignored. Expand
Transfollicular Drug Delivery: Penetration of Drugs Through Human Scalp Skin and Comparison of Penetration Between Scalp and Abdominal Skins In Vitro
Results indicate that the drug delivery through the scalp skin will offer an available delivery means for drugs, particularly for hydrophilic drugs. Expand
Effect of various enhancers on transdermal penetration of indomethacin and urea, and relationship between penetration parameters and enhancement factors.
In vitro permeation experiments with hairless rat skin unequivocally revealed that the enhancers varied in abilities to enhance the fluxes of both agents, but N-methyl-2-pyrrolidone, N,N-diethyl-m-tolamide, and oleyl oleate were less effective acclerants. Expand
Mechanism for the enhancement effect of fatty acids on the percutaneous absorption of propranolol.
The effects of a series of fatty acids on the percutaneous absorption of propranolol (PL) through rabbit skin and the mechanism by which fatty acids facilitate the skin penetration of PL wereExpand
Effect of Positively and Negatively Charged Liposomes on Skin Permeation of Drugs
Histological studies revealed that the negatively charged liposomes diffused to the dermis and the lower portion of hair follicles through the stratum corneum and the follicles much faster than the positive vesicles at the intitial time stage after application, which would contribute to the increased permeation of drugs through the skin. Expand
Transdermal absorption of bupranolol in rabbit skin in vitro and in vivo.
The transdermal systems will offer an efficient drug delivery system for the treatment of angina pectoris and tachycardia because the plasma levels of BP determined were extremely lower than the theoretical plasma steady-state concentrations predicted. Expand
A pharmacokinetic model for the percutaneous absorption of indomethacin and the prediction of drug disposition kinetics.
The model, applied to data obtained after percutaneous dosing of ointments under occlusion, successfully described the plasma profile observed in the presence and absence of laurocapram and sorbitan monooleate and the penetration characteristics through stripped skin were well described by the model. Expand
Fluidity of human erythrocyte membrane and effect of chlorpromazine on fluidity and phase separation of membrane.
The results suggest that the boundary phospholipids of the Mg2+-ATPase in the membrane are probably more rigid than the bulk lipids. Expand
Encapsulation of dexamethasone in rabbit erythrocytes, the disposition in circulation and anti-inflammatory effect.
The results indicated that resealed erythrocytes act as a slow release system in vivo, and the encapsulated cells were protected from inflammation (the capillary permeability response) caused by histamine for approximately 2 to 5 d after administration. Expand
Effect of dicyclomine on intestinal absorption, disposition and biliary excretion of dexamethasone.
The effect of dicyclomine, a cholinergic blocking agent, on the in situ intestinal absorption, plasma clearance, biliary excretion, and renal plasma flow in coadministration group was significantly enhanced compared with that of dexamethasone alone. Expand