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Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed upExpand
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Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic bloodExpand
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Angiotensin II accelerates osteoporosis by activating osteoclasts
Recent clinical studies suggest that several antihypertensive drugs, especially angiotensin‐converting enzyme inhibitors, reduced bone fractures. To clarify the relationship between hypertension andExpand
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Hypoadiponectinemia Is an Independent Risk Factor for Hypertension
Adiponectin is one of the key molecules in the metabolic syndrome, and its concentration is decreased in obesity, type-2 diabetes, and coronary artery disease. Genetic investigation has revealed thatExpand
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In vivo transfection of cis element “decoy” against nuclear factor- κB binding site prevents myocardial infarction
The transcriptional factor nuclear factor-κB (NFκB) plays a pivotal role in the coordinated trans-activation of cytokine and adhesion molecule genes that might be involved in myocardial damage afterExpand
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Novel Autologous Cell Therapy in Ischemic Limb Disease Through Growth Factor Secretion by Cultured Adipose Tissue-derived Stromal Cells: P198
Objective—The delivery of autologous progenitor cells into ischemic tissue of patients is emerging as a novel therapeutic option. Here, we report the potential impact of cultured adiposeExpand
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[Angiotensin II type 1 receptor gene].
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Blood Pressure and Hypertension Are Associated With 7 Loci in the Japanese Population
Background— Two consortium-based genome-wide association studies have recently identified robust and significant associations of common variants with systolic and diastolic blood pressures inExpand
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Genome-wide association study of coronary artery disease in the Japanese
A new understanding of the genetic basis of coronary artery disease (CAD) has recently emerged from genome-wide association (GWA) studies of common single-nucleotide polymorphisms (SNPs), thus farExpand
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Target Blood Pressure for Treatment of Isolated Systolic Hypertension in the Elderly: Valsartan in Elderly Isolated Systolic Hypertension Study
In this prospective, randomized, open-label, blinded end point study, we aimed to establish whether strict blood pressure control (<140 mm Hg) is superior to moderate blood pressure control (≥140 mmExpand
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