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Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
A meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry followed up with de novo genotyping and further replication in east Asian samples provides new insights into blood pressure regulation and potential targets for intervention. Expand
Angiotensin II accelerates osteoporosis by activating osteoclasts
Overall, Ang II accelerates osteoporosis by activating osteoclasts via RANKL induction, and blockade of Ang II might become a novel therapeutic approach to prevent osteopOrosis in hypertensive patients. Expand
Hypoadiponectinemia Is an Independent Risk Factor for Hypertension
Hypoadiponectinemia is a marker for predisposition to hypertension in men and blood pressure was inversely associated with adiponectin concentration in normotensives regardless of insulin resistance. Expand
[Bartter syndrome].
The characteristic clinical features of Bartter syndrome consist of hypokalemia, hypochloremic metabolic alkalosis, and normal blood pressure despite hyperreninemia and hyperaldosteronism, while others such as hypomagnesemia are observed in some cases. Expand
Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk
A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function, and these findings suggest potential novel therapeutic pathways for cardiovascular disease prevention. Expand
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009)
The Japanese Society of Hypertension Guidelines for the Management ofhypertension (JSH 2009) provide guidelines for the management ofpertension in patients with high blood pressure. Expand
In vivo transfection of cis element “decoy” against nuclear factor- κB binding site prevents myocardial infarction
The first successful in vivo transfer of NFκB decoy oligodeoxynucleotides to reduce the extent of myocardial infarction following reperfusion is reported, providing a new therapeutic strategy for myocardia infarctions. Expand
Genome-wide association study of coronary artery disease in the Japanese
Three loci confirmed in the Japanese GWA study highlight the likely presence of risk alleles with two types of genetic effects – population specific and common – on susceptibility to CAD. Expand
[Angiotensin II type 1 receptor gene].
Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia.
It is documents that a single intraluminal molecular delivery of combined cdc2 kinase and PCNA antisense ODNs results in a sustained inhibition of neointima formation in the rat carotid balloon-injury model. Expand