Share This Author
Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk
A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function, and these findings suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
A meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry followed up with de novo genotyping and further replication in east Asian samples provides new insights into blood pressure regulation and potential targets for intervention.
Angiotensin II accelerates osteoporosis by activating osteoclasts
- H. Shimizu, H. Nakagami, R. Morishita
- Biology, MedicineFASEB journal : official publication of the…
- 1 July 2008
Overall, Ang II accelerates osteoporosis by activating osteoclasts via RANKL induction, and blockade of Ang II might become a novel therapeutic approach to prevent osteopOrosis in hypertensive patients.
In vivo transfection of cis element “decoy” against nuclear factor- κB binding site prevents myocardial infarction
The first successful in vivo transfer of NFκB decoy oligodeoxynucleotides to reduce the extent of myocardial infarction following reperfusion is reported, providing a new therapeutic strategy for myocardia infarctions.
The characteristic clinical features of Bartter syndrome consist of hypokalemia, hypochloremic metabolic alkalosis, and normal blood pressure despite hyperreninemia and hyperaldosteronism, while others such as hypomagnesemia are observed in some cases.
Hypoadiponectinemia Is an Independent Risk Factor for Hypertension
Hypoadiponectinemia is a marker for predisposition to hypertension in men and blood pressure was inversely associated with adiponectin concentration in normotensives regardless of insulin resistance.
Genome-wide association study of coronary artery disease in the Japanese
Three loci confirmed in the Japanese GWA study highlight the likely presence of risk alleles with two types of genetic effects – population specific and common – on susceptibility to CAD.
Association of Hypoadiponectinemia With Impaired Vasoreactivity
Observations suggest that hypoadiponectinemia is associated with impaired endothelium-dependent vasorelaxation and that the measurement of plasma adiponectin level might be helpful as a marker of endothelial dysfunction.
Blood Pressure and Hypertension Are Associated With 7 Loci in the Japanese Population
These loci can guide fine-mapping efforts to pinpoint causal variants and causal genes with the integration of multiethnic results and reach a conclusive level of statistical significance after adjustment for multiple testing.
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
Examination of genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolicBlood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs supports the notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity.