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Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD.
BACKGROUND FEV(1) is regarded as the most significant correlate of survival in COPD and is used as a measure of disease severity in the staging of COPD. Recently, however, the categorization ofExpand
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Analysis of the factors related to mortality in chronic obstructive pulmonary disease: role of exercise capacity and health status.
In this study, we analyzed the relationships of exercise capacity and health status to mortality in patients with chronic obstructive pulmonary disease (COPD). We recruited 150 male outpatients withExpand
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TRPA1 underlies a sensing mechanism for O2.
Oxygen (O(2)) is a prerequisite for cellular respiration in aerobic organisms but also elicits toxicity. To understand how animals cope with the ambivalent physiological nature of O(2), it isExpand
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Longitudinal deteriorations in patient reported outcomes in patients with COPD.
Goals of effective management of patients with chronic obstructive pulmonary disease (COPD) include relieving their symptoms and improving their health status. We examined how such patient reportedExpand
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A comparison of the level of dyspnea vs disease severity in indicating the health-related quality of life of patients with COPD.
STUDY OBJECTIVES To compare categorizations of the level of dyspnea with the staging of disease severity as defined by the FEV(1) in representing how the health-related quality of life (HRQOL) isExpand
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Stages of disease severity and factors that affect the health status of patients with chronic obstructive pulmonary disease.
BACKGROUND We hypothesized that the factors which may influence health status would differ in patients at different disease stages of chronic obstructive pulmonary disease (COPD). The present studyExpand
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Relationship between Small Airway Function and Health Status, Dyspnea and Disease Control in Asthma
Background: Small airways play important roles in the pathophysiology of asthma. However, relationships between small airway involvement and health status and dyspnea have not been investigated.Expand
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The effects of oxitropium bromide on exercise performance in patients with stable chronic obstructive pulmonary disease. A comparison of three different exercise tests.
The purpose of the present study was to compare the characteristics of three different exercise tests in evaluating the effects of oxitropium bromide on exercise performance. Thirty-eight males withExpand
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Exercise capacity deterioration in patients with COPD: longitudinal evaluation over 5 years.
BACKGROUND Although exercise capacity is an important outcome measure in patients with COPD, its longitudinal course has not been analyzed in comparison to the change in pulmonary function. Expand
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HRCT features of interstitial lung disease in dermatomyositis with anti-CADM-140 antibody.
BACKGROUND Anti-CADM-140 antibody (anti-CADM-140), also referred to as anti-melanoma differentiation-associated gene 5 (MDA5) antibody, is a myositis-specific antibody identified in the sera ofExpand
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