T. O’Halloran

Publications265
h-index74
Citations20,414
Highly Influential Citations795
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The Independent cue and cusSystems Confer Copper Tolerance during Aerobic and Anaerobic Growth inEscherichia coli *
TLDR
The cytosolic (CueR) and periplasmic (CusRS) sensor systems differentially regulate copper export systems in response to changes in copper and oxygen availability, underscore the increased toxicity of copper under anaerobic conditions and the complex adaptation of copper export in E. coli.
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Molecular Basis of Metal-Ion Selectivity and Zeptomolar Sensitivity by CueR
TLDR
An unusual buried metal-receptor site in CueR restricts the metal to a linear, two-coordinate geometry and uses helix-dipole and hydrogen-bonding interactions to enhance metal binding, which is rare among metalloproteins but well suited for an ultrasensitive genetic switch.
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Transcriptional Activation of an Escherichia coliCopper Efflux Regulon by the Chromosomal MerR Homologue, CueR*
TLDR
YbbI is designated ybbIas cueR for the Cu effluxregulator and represents the first example of a copper-responsive regulon on the E. coli chromosome and further extends the roles of MerR family members in prokaryotic stress response.
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Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase.
TLDR
Results indicate that intracellular [Cu]free is limited to less than one free copper ion per cell and suggest that a pool of free copper ions is not used in physiological activation of metalloenzymes.
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Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria.
TLDR
Findings provide evidence of direct links among oxidation, protein aggregation, mitochondrial damage, and SOD1-mediated ALS, with possible applications to the aging process and other late-onset neurodegenerative disorders, and rational therapy can now be developed and tested.
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Identification of a Copper-Responsive Two-Component System on the Chromosome of Escherichia coli K-12
TLDR
Two chromosomal genes are identified from Escherichia coli K-12 that encode a two-component, signal transduction system that is responsive to copper ions that is required for copper-induced expression of pcoE, a plasmid-borne gene from the E. coli copper resistance operon pco.
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Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors
The essential transition metal ions are avidly accumulated by cells, yet they have two faces: They are put to use as required cofactors, but they also can catalyze cytotoxic reactions. Several…
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Oxygen‐induced maturation of SOD1: a key role for disulfide formation by the copper chaperone CCS
TLDR
It is shown that the disulfide status of Saccharomyces cerevisiae SOD1 significantly affects the monomer–dimer equilibrium, the interaction with the copper chaperone CCS, and the activity of the enzyme itself.
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Activation of superoxide dismutases: putting the metal to the pedal.
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Heterodimeric structure of superoxide dismutase in complex with its metallochaperone
TLDR
Striking conformational rearrangements are observed in both the chaperone and target enzyme upon complex formation, and the functionally essential C-terminal domain of yCCS is well positioned to play a key role in the metal ion transfer mechanism.
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