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Smoking-Dependent Reprogramming of Alveolar Macrophage Polarization: Implication for Pathogenesis of Chronic Obstructive Pulmonary Disease1
When exposed to a specific microenvironment, macrophages acquire either M1- or M2-polarized phenotypes associated with inflammation and tissue remodeling, respectively. Alveolar macrophages (AM)Expand
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Microtubule behavior during guidance of pioneer neuron growth cones in situ
The growth of an axon toward its target results from the reorganization of the cytoskeleton in response to environmental guidance cues. Recently developed imaging technology makes it possible toExpand
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Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease.
RATIONALE The airway epithelium of smokers is subject to a variety of mechanisms of injury with consequent modulation of epithelial regeneration and disordered differentiation. Several signalingExpand
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Ephus: Multipurpose Data Acquisition Software for Neuroscience Experiments
Ephus is an open-source software package designed for general-purpose data acquisition and instrument control. Expand
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Variability of antioxidant-related gene expression in the airway epithelium of cigarette smokers.
Cigarette smoking is the major risk factor for developing chronic bronchitis, yet only 15-20% of smokers develop this disorder. Because oxidants are the major mechanism of smoking-induced airwayExpand
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Gene expression profiling of human alveolar macrophages of phenotypically normal smokers and nonsmokers reveals a previously unrecognized subset of genes modulated by cigarette smoking
Cigarette smoking is the leading cause of the respiratory diseases collectively known as chronic obstructive pulmonary disease (COPD). While the pathogenesis of COPD is complex, there is abundantExpand
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Neurite consolidation is an active process requiring constant repression of protrusive activity
During development, neurons extend projections that pathfind to reach their appropriate targets. These projections are composed of two distinct domains: a highly dynamic growth cone and a stableExpand
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Aetiology and management of hypertrophic scars and keloids.
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Discrete roles for secreted and transmembrane semaphorins in neuronal growth cone guidance in vivo.
From the initial stages of axon outgrowth to the formation of a functioning synapse, neuronal growth cones continuously integrate and respond to multiple guidance cues. To investigate the role ofExpand
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Cytoskeletal events in growth cone steering
Oriented neural outgrowth is dependent upon the capability of growth cones to reorient the direction of their migration in response to contact with guidance information. Recent observations haveExpand
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