Localization of the Epileptic Focus by Low-Resolution Electromagnetic Tomography in Patients with a Lesion Demonstrated by MRI
Patients with medically intractable partial epilepsy and well-defined symptomatic MRI lesions were studied using phase-encoded frequency spectral analysis (PEFSA) combined with low-resolution electromagnetic tomography (LORETA), which can localize ictal EEG discharges accurately and improve correlation with brain anatomy by allowing coregistration of the ictAl generator with the MRI.
Prediction of seizure likelihood with a long-term, implanted seizure advisory system in patients with drug-resistant epilepsy: a first-in-man study
Epilepsy in adults
MRI-negative PET-positive temporal lobe epilepsy: a distinct surgically remediable syndrome.
HS-ve PET-positive TLE may be a surgically remediable syndrome distinct from HS+ve TLE, with a pathophysiological basis that primarily involves lateral temporal neocortical rather than mesial temporal structures.
Factors Predictive of the Outcome of Frontal Lobe Epilepsy Surgery
To identify factors that predict the outcome in seizure control after frontal lobe epilepsy surgery (FLES), a large number of patients with severe epilepsy are treated with FLES.
Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy
This study provides Class I evidence that adjunctive perampanel reduces PGTC seizure frequency, compared with placebo, in patients with drug-resistant PGTC seizures in IGE.
Mutations in DEPDC5 cause familial focal epilepsy with variable foci
Study of families with focal epilepsy that were too small for conventional clinical diagnosis with FFEVF identified DEPDC5 mutations in approximately 12% of families, establishing high frequency mutations as a common cause of familial focal epilepsies.
NMDA Receptor Hypofunction Leads to Generalized and Persistent Aberrant γ Oscillations Independent of Hyperlocomotion and the State of Consciousness
Findings suggest that NMDAr hypofunction-related generalized γ hypersynchronies represent an aberrant diffuse network noise, a potential electrophysiological correlate of a psychotic-like state that might cause dysfunction of brain operations, including the impairments in cognition and sensorimotor integration seen in schizophrenia.
Experimental traumatic brain injury induces a pervasive hyperanxious phenotype in rats.
- N. Jones, L. Cardamone, John P. Williams, M. Salzberg, D. Myers, T. O’Brien
- Psychology, BiologyJournal of Neurotrauma
- 5 December 2008
This report provides the first evidence of persistent anxiety-like disturbances in an experimental model of TBI, indicating that the common occurrence of these symptoms in human sufferers is likely to have, at least in part, a neurobiological basis.
Clinical Characteristics and Outcome in Patients With Psychogenic Nonepileptic Seizures
The need for earlier diagnosis of PNES and comorbidities is demonstrated and the need for diagnostic and therapeutic approaches that combine neurological and psychiatric perspectives is highlighted.