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The ST6GalNAc-I Sialyltransferase Localizes throughout the Golgi and Is Responsible for the Synthesis of the Tumor-associated Sialyl-Tn O-Glycan in Human Breast Cancer*
The functional properties of glycoproteins are strongly influenced by their profile of glycosylation, and changes in this profile are seen in malignancy. In mucin-type O-linked glycosylation theseExpand
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cAMP/PKA antagonizes thrombin-induced inactivation of endothelial myosin light chain phosphatase: role of CPI-17.
AIMS Activation of cAMP signalling abrogates thrombin-induced hyperpermeability. One of the mechanisms underlying this protective effect is the inactivation of endothelial contractile machinery, oneExpand
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ATP antagonism of thrombin-induced endothelial barrier permeability.
OBJECTIVES Thrombin induces endothelial barrier failure by activating the contractile machinery of endothelial cells. Contractile activation is due to an increase in myosin light chain (MLC)Expand
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Blockade of Ca2+-Activated K+ Channels Inhibits Proliferation of Human Endothelial Cells Induced by Basic Fibroblast Growth Factor
Basic fibroblast growth factor (bFGF) exerts angiogenic and mitogenic properties in human tissue. Since changes in ion currents modulate essential Ca2+-dependent intracellular pathways in endothelialExpand
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Intermedin/adrenomedullin-2 is a hypoxia-induced endothelial peptide that stabilizes pulmonary microvascular permeability.
  • U. Pfeil, M. Aslam, +12 authors W. Kummer
  • Biology, Medicine
  • American journal of physiology. Lung cellular and…
  • 1 November 2009
Accumulating evidence suggests a pivotal role of the calcitonin receptor-like receptor (CRLR) signaling pathway in preventing damage of the lung by stabilizing pulmonary barrier function. IntermedinExpand
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Effect of Factor XIII on Endothelial Barrier Function
The effect of factor XIII on endothelial barrier function was studied in a model of cultured monolayers of porcine aortic endothelial cells and saline-perfused rat hearts. The thrombin-activatedExpand
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Finger Length Ratio (2D:4D) in Adults with Gender Identity Disorder
From early childhood, gender identity and the 2nd to 4th finger length ratio (2D:4D) are discriminative characteristics between sexes. Both the human brain and 2D:4D may be influenced by prenatalExpand
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Metabolic and Pathological Aspects of Hypoxia in Liver Cells
The liver parenchymal cell, subsequently referred to as the liver cell, is among those mammalian cells which are dependent in their functions upon molecular oxygen. Hypoxia, i.e., O2 deficiency, isExpand
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Fast filtration for metabolome sampling of suspended animal cells
A new method for sampling suspended animal cells by fast filtration is presented that allows rapid quenching of cellular metabolism and efficient separation of the cells from culture medium. ComparedExpand
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Stimulation of cGMP signalling protects coronary endothelium against reperfusion-induced intercellular gap formation.
AIMS Ischaemia-reperfusion provokes barrier failure of the coronary microvasculature, impeding functional recovery of the heart during reperfusion. The aim of the present study was to investigateExpand
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