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The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor.
Evidence that a member of the fibroblast growth factor (FGF) family emanates from the prospective limb mesoderm to serve as an endogenous initiator for limb bud formation is provided and results suggest that FGF10 is a key mesenchymal factor involved in the initial budding as well as the continuous outgrowth of vertebrate limbs. Expand
The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium.
The embryonic gut of vertebrates consists of endodermal epithelium, surrounding mesenchyme derived from splanchnic mesoderm and enteric neuronal components derived from neural crest cells. During gutExpand
Involvement of Wnt‐5a in chondrogenic pattern formation in the chick limb bud
Results suggest that chicken Wnt‐5a is involved in pattern formation along the proximal–distal axis by regulation of chondrogenic differentiation. Expand
Identification of a Human Type II Receptor for Bone Morphogenetic Protein-4 That Forms Differential Heteromeric Complexes with Bone Morphogenetic Protein Type I Receptors (*)
A cDNA encoding a novel transmembrane serine/threonine kinase from human skin fibroblasts is isolated and demonstrated here to be a type II receptor that binds BMP-4, suggesting that the different heteromeric BMP receptor complexes have different signaling potential. Expand
Wnt regulation of chondrocyte differentiation
The Wnt family of growth factors are important regulators of several developmental processes including skeletogenesis and their expression in the developing chick limb is analysed and functional analyses in vivo and in vitro showed that Wnt5b and Wnt11 control chondrogenesis in parallel pathways. Expand
Involvement of androgen-induced growth factor (FGF-8) gene in mouse embryogenesis and morphogenesis.
The embryonic expression pattern suggests a unique role of FGF-8 in mouse development, especially in gastrulation, brain development, and limb and facial morphogenesis. Expand
The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis.
The data demonstrate that Frzb-1 exerts a strong influence on limb skeletogenesis and is a powerful and direct modulator of chondrocyte maturation, phenotype, and function. Expand
Identification of cis‐element regulating expression of the mouse Fgf10 gene during inner ear development
FGF10 signaling is dispensable for specification of otic compartment identity but is required for hollowing the semicircular disk, and the analysis of a putative inner ear enhancer of Fgf10 has disclosed a complicated regulation of FGF10 during inner ear development by numerous transcription factors and signaling pathways. Expand
BMP signaling during bone pattern determination in the developing limb.
Although the bone pattern was not disturbed by expressing individual dominant-negative BRK independently, preferential distal and posterior limb truncations resulted from co-expressing the dominant- negative forms of BRK-2 andBRK-3 in the whole limb bud, thus providing evidence that BMPs are essential morphogenetic signals for limb bone patterning. Expand
A chicken Wnt gene, Wnt-11, is involved in dermal development.
A new member of the Wnt gene family is isolated from chick embryo cDNA library and the expression pattern during embryogenesis by in situ hybridization suggests that Wnt-11 may play an important role in dermal development. Expand