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Use of Escherichia coli polyphosphate kinase for oligosaccharide synthesis.
The Escherichia coli polyphosphate kinase (PPK) has been known to catalyze the reversible transfer of phosphate molecules between ATP and polyphosphate (poly(P)). It has also been found that the PPK… Expand
A novel ATP regeneration system using polyphosphate-AMP phosphotransferase and polyphosphate kinase.
- A. Kameda, T. Shiba, +5 authors T. Noguchi
- Medicine, Biology
- Journal of bioscience and bioengineering
Polyphosphate-AMP phosphotransferase (PAP) and polyphosphate kinase (PPK) were used for designing a novel ATP regeneration system, named the PAP-PPK ATP regeneration system. PAP is an enzyme that… Expand
Inorganic polyphosphate and polyphosphate kinase: their novel biological functions and applications.
In this review, we discuss the following two subjects: 1) the physiological function of polyphosphate (poly(P)) as a regulatory factor for gene expression in Escherichia coli, and 2) novel functions… Expand
The polyphosphate kinase gene of Pseudomonas aeruginosa.
- K. Ishige, A. Kameda, T. Noguchi, T. Shiba
- Biology, Medicine
- DNA research : an international journal for rapid…
We have cloned and sequenced a gene encoding polyphosphate kinase (PPK) from Pseudomonas aeruginosa PAO1. The gene immediately follows the hemB gene encoding porphobilinogen synthase responsible for… Expand
Biosynthetic pathways of brassinolide in Arabidopsis.
Our previous studies on the endogenous brassinosteroids (BRs) in Arabidopsis have provided suggestive evidence for the operation of the early C6-oxidation and the late C6-oxidation pathways, leading… Expand
Novel Method for Enzymatic Synthesis of CMP-NeuAc
- K. Ishige, T. Hamamoto, T. Shiba, T. Noguchi
- Medicine, Chemistry
- Bioscience, biotechnology, and biochemistry
- 1 January 2001
A novel method for synthesizing CMP-NeuAc was established. We first confirmed that the putative neuA gene of Haemophilus influenzae, identified by its whole genome sequence project, indeed encodes… Expand
Convergent and stereoselective method for synthesis of O-linked oxepane ring system by intramolecular radical cyclization
Abstract A new strategy for the construction of O -linked oxepane ring system is described. The present method involves regioselective acetal cleavage by i -Bu 2 AlSePh and intramolecular radical… Expand
Synthesis of the FGH ring fragment of ciguatoxin
Abstract Stereoselective synthesis of the FGH ring fragment of ciguatoxin is described. The key steps in the present synthesis are an intramolecular radical cyclization to construct oxepane ring G… Expand
Intramolecular radical cyclization-ring-closing metathesis approach to fused polycyclic ethers. Convergent synthesis and conformational analysis of the (E)FGH ring system of ciguatoxin.
A convergent synthetic route to the (E)FGH ring system 4 of ciguatoxins, the causative toxins for ciguatera fish poisoning, has been developed. The synthesis features convergent coupling to form… Expand
Indoline derivatives II: synthesis and factor Xa (FXa) inhibitory activities.
- T. Noguchi, N. Tanaka, +7 authors Koichi Fujimoto
- Chemistry, Medicine
- Chemical & pharmaceutical bulletin
- 1 February 2006
Factor Xa (FXa) is well known to play a pivotal role in blood coagulation, so FXa inhibitor is a promising drug candidate for prophylaxis and treatment of thromboembolic diseases. In the course of… Expand