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QSAR evaluation of the Ch'an Su and related bufadienolides against the colchicine-resistant primary liver carcinoma cell line PLC/PRF/5(1).
QSAR analysis has been used to identify the essential structural requirements for increasing the inhibitory activities of selected bufadienolides from the Chinese drug Ch'an Su (and other sources)
Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein.
TLDR
The finding that XN bound to and inactivated VCP not only reveals the molecular mechanism of XN-modulated autophagy but may also explain how XN exhibits various biological activities that have been reported previously.
A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis.
TLDR
It is demonstrated that fsa2, which showed no homology to genes encoding proteins of known function, in the fsa cluster responsible for equisetin and fusarisetin A biosynthesis in Fusarium sp.
Identification of a Molecular Target of a Novel Fungal Metabolite, Pyrrolizilactone, by Phenotypic Profiling Systems
TLDR
It is determined that pyrrolizilactone is a novel type of proteasomesome inhibitor inhibiting the trypsin‐like activity of the proteasome.
Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su.
TLDR
Five new bufadienolides, 3beta-formyloxyresibufogenin, 19-oxobufalin, 6alpha-hydroxycinobufagin, and 1beta-Hydroxybufalin, have been isolated together with the previously known bufadienneolides 6-20 from the Chinese traditional drug "Ch'an Su", and the structures were elucidated employing spectroscopic methods.
Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation.
TLDR
This work comprehensively describes the spiroacetal formation involved in the biosynthesis of reveromycin A, which inhibits bone resorption and bone metastases of tumor cells by inducing apoptosis in osteoclasts and provides insights into the creation of a variety of biologically active spiro acetal compounds for drug leads.
Biochemical Characterization of a Novel Indole Prenyltransferase from Streptomyces sp. SN-593
TLDR
The metabolite-guided genome mining and functional characterization of a cryptic gene by biochemical studies are reported, suggesting that the iptA gene is involved in the production of 6-DMAI-3-carbaldehyde.
Resibufogenin Corrects Hypertension in a Rat Model of Human Preeclampsia
TLDR
A rat model of preeclampsia in which the excretion of a circulating inhibitor of Na/K ATPase, marinobufagenin (MBG), is elevated is developed, revealing that these agents are equally effective as inhibitors of the enzyme.
Temperature during conidiation affects stress tolerance, pigmentation, and trypacidin accumulation in the conidia of the airborne pathogen Aspergillus fumigatus
TLDR
Data show that the environmental temperature during conidiation affects conidial properties such as stress tolerance, pigmentation, and mycotoxin accumulation.
RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening
TLDR
These are the first examples for natural products as a quinoline type quinomycin having a sulfoxide on the intramolecular cross-linkage and showed potent antiproliferative activities against various cancer cell lines and they were also found to exhibit moderate antibacterial activity.
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