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Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells.
Altered patterns of DNA methylation associated with Helicobacter pylori (HP) infection of gastric epithelial cells are thought to contribute to gastric cancer risk. However, it is unclear whetherExpand
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Recurrent mutations of CD79B and MYD88 are the hallmark of primary central nervous system lymphomas
Primary central nervous system lymphoma (PCNSL) manifest aggressive clinical behaviour and have poor prognosis. Although constitutive activation of the nuclear factor‐κB (NF‐κB) pathway has beenExpand
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Frequent involvement of chromatin remodeler alterations in gastric field cancerization.
A field for cancerization, or a field defect, is formed by the accumulation of genetic and epigenetic alterations in normal-appearing tissues, and is involved in various cancers, especially multipleExpand
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The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae
Aberrant DNA methylation is deeply involved in human cancers, but its inducers and targets are still mostly unclear. Helicobacter pylori infection was recently shown to induce aberrant methylation inExpand
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Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation.
Chronic inflammation is deeply involved in induction of aberrant DNA methylation, but it is unclear whether any type of persistent inflammation can induce methylation and how induction of cellExpand
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The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands.
Instructive mechanisms are present for induction of DNA methylation, as shown by methylation of specific CpG islands (CGIs) by specific inducers and in specific cancers. However, instructive factorsExpand
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Early-stage formation of an epigenetic field defect in a mouse colitis model, and non-essential roles of T- and B-cells in DNA methylation induction
Epigenetic fields for cancerization are involved in development of human cancers, especially those associated with inflammation and multiple occurrences. However, it is still unclear when such fieldExpand
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Methylation silencing of transforming growth factor-beta receptor type II in rat prostate cancers.
To identify methylation-silenced genes in prostate cancers, a microarray analysis for genes up-regulated by treatment with a demethylating agent, 5-aza-2'-deoxycytidine, was performed using three ratExpand
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Elevated risk of colorectal adenoma with Helicobacter pylori‐related chronic gastritis: A population‐based case‐control study
This study investigated correlations between Helicobacter pylori infection or chronic atrophic gastritis (CAG) and risk of colorectal adenoma in a population‐based case‐control study. SubjectsExpand
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Inhibitory effects of Japanese apricot (Prunus mume Siebold et Zucc.; Ume) on Helicobacter pylori-related chronic gastritis
Objectives:We investigated the correlation between Japanese apricot (JA) intake and Helicobacter pylori-related chronic atrophic gastritis (CAG).Methods:A questionnaire was administered and serumExpand
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