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Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo.
Findings indicate that CTGF is a novel, potent angiogenesis factor which functions in multi-stages in this process. Expand
Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis.
- H. Yokoi, M. Mukoyama, +9 authors K. Nakao
- Medicine, Chemistry
- Journal of the American Society of Nephrology…
- 1 June 2004
Findings indicate that CTGF expression in the interstitium plays a crucial role in the progression of interstitial fibrosis but not in the proliferation of tubular and interstitial cells during UUO, and may become a potential therapeutic target against tubulointerstitial fibrosis. Expand
Inhibition of endogenous expression of connective tissue growth factor by its antisense oligonucleotide and antisense RNA suppresses proliferation and migration of vascular endothelial cells.
Findings suggest that endogenous CTGF expression is involved in the proliferation and migration of BAE cells, which were stably transfected with expression vectors that generate the antisense RNA of CTGF cDNA. Expand
Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells
- M. Asano, S. Kubota, +7 authors M. Takigawa
- Medicine, Biology
- Cell Communication and Signaling
- 5 October 2005
Important roles of CCN2/CTGF in the development and regeneration of periodontal tissue including theperiodontal ligament are suggested. Expand
Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture.
Results indicate that CTGF/Hcs24 directly promotes the proliferation and differentiation of chondrocytes and effectively increased alkaline phosphatase activity in RGC cells in culture. Expand
CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes
- T. Nishida, H. Kawaki, R. Baxter, R. Deyoung, M. Takigawa, K. Lyons
- Biology, Medicine
- Journal of Cell Communication and Signaling
- 16 May 2007
It is argued that CCN2 exerts major effects in chondrocytes through its ability to regulate ECM production and integrin α5 expression, engage integrins and activate integrin-mediated signaling pathways. Expand
Involvement of CTGF, a Hypertrophic Chondrocyte-Specific Gene Product, in Tumor Angiogenesis
The results suggest that CTGF regulates progression in tumorAngiogenesis and the release or secretion of CTGF from tumor cells is essential for the angiogenesis. Expand
Binding of glyceraldehyde-3-phosphate dehydrogenase to the cis-acting element of structure-anchored repression in ccn2 mRNA.
- S. Kondo, S. Kubota, +5 authors M. Takigawa
- Biology, Medicine
- Biochemical and biophysical research…
- 18 February 2011
Findings suggest that the glycolytic enzyme GAPDH regulates the gene expression of ccn2 mRNA in trans by acting as a sensor of oxidative stress and redox signals, leading to CCN2 overexpression under the condition of hypoxia and promotion of angiogenesis. Expand
Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade.
- Hiroshi Kobayashi, Mika Suzuki, N. Kanayama, T. Nishida, M. Takigawa, T. Terao
- Chemistry, Medicine
- European journal of biochemistry
- 1 August 2002
Bikunin downregulates constitutive and PMA-stimulated uPAR mRNA and protein possibly through suppression of upstream targets of the ERK-dependent cascade, independent of whether cells were treated with exogenous bikunin or transfected with bkunin gene. Expand
CCN2 enhances RANKL-induced osteoclast differentiation via direct binding to RANK and OPG.
Findings suggest CCN2 as a candidate of the fourth factor in the RANK/RANKL/OPG system for osteoclastogenesis, which regulates OPG and RANK via direct interaction. Expand