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The vacuolar (H+)-ATPases — nature's most versatile proton pumps
The pH of intracellular compartments in eukaryotic cells is a carefully controlled parameter that affects many cellular processes, including intracellular membrane transport, prohormone processing…
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The Amino-terminal Domain of the Vacuolar Proton-translocating ATPase a Subunit Controls Targeting and in Vivo Dissociation, and the Carboxyl-terminal Domain Affects Coupling of Proton Transport and…
TLDR
The results suggest that whereas targeting and in vivo dissociation are controlled by sequences located in the amino-terminal domains of the subunit a isoforms, coupling efficiency is controlled by the carboxyl-Terminal region.
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Yeast V-ATPase Complexes Containing Different Isoforms of the 100-kDa a-subunit Differ in Coupling Efficiency and in VivoDissociation*
TLDR
The results suggest that dissociation of the V-ATPase complex in vivo is controlled both by the cellular environment and by the 100-kDa a-subunit isoform present in the complex.
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The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors
TLDR
It is shown that the export of S1P from cells requires Spns2, and the introduction of spns2 mRNA in the YSL restored the cardiac defect in the ko157 mutant, thereby regulating myocardial precursor migration.
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Arg-735 of the 100-kDa subunit a of the yeast V-ATPase is essential for proton translocation
TLDR
It is suggested that Arg-735 is absolutely required for proton transport by the V-ATPases and is discussed in the context of a revised model of the topology of the 100-kDa subunit a.
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Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells
TLDR
It is shown that SPNS2 functions as an S1P transporter in vascular endothelial cells but not in erythrocytes and platelets and is a key determinant of lymphocyte egress from the thymus.
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Proton translocation driven by ATP hydrolysis in V‐ATPases
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Characterization of the ATP-dependent Sphingosine 1-Phosphate Transporter in Rat Erythrocytes*
TLDR
Results suggest that S1P is exported from the erythrocytes by a novel ATP-dependent transporter, which plays an important role in lymphocyte egress from lymphoid organs.
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Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner Published, JLR Papers in Press, December 21, 2005.
TLDR
The results indicate that S1P is localized in the inner leaflet of the plasma membrane and that its release is a carrier-mediated process, and that two independent S 1P release systems might exist in the platelet plasma membrane, an ATP-dependent system stimulated by thrombin and a ATP-independent system stimulating by Ca2+.
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The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.
TLDR
This work demonstrates that human SPNS2 can transport several S1P analogues, including FTY720-P, and identifies the first identification of an FTY 720-P transporter in cells.
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