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Robust transcriptome-wide discovery of RNA binding protein binding sites with enhanced CLIP (eCLIP)
As RNA-binding proteins (RBPs) play essential roles in cellular physiology by interacting with target RNA molecules, binding site identification by UV crosslinking and immunoprecipitation (CLIP) of… Expand
Surgeons' tone of voice: a clue to malpractice history.
- N. Ambady, Debi A. LaPlante, T. Nguyen, R. Rosenthal, N. Chaumeton, W. Levinson
- Medicine, Psychology
- 1 July 2002
BACKGROUND Interpersonal aspects of care, such as the communication behaviors of physicians, are often cited as central to patients' decisions to initiate malpractice litigation. Relatively little is… Expand
Switching to coformulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus continuation of non-nucleoside reverse transcriptase inhibitor with emtricitabine and tenofovir in…
BACKGROUND Coformulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate (tenofovir) might be a safe and efficacious switch option for virologically suppressed patients with… Expand
Identification of Novel Long Noncoding RNAs Underlying Vertebrate Cardiovascular Development
Background— Long noncoding RNAs (lncRNAs) have emerged as critical epigenetic regulators with important functions in development and disease. Here, we sought to identify and functionally characterize… Expand
A Large-Scale Binding and Functional Map of Human RNA Binding Proteins
Genomes encompass all the information necessary to specify the development and function of an organism. In addition to genes, genomes also contain a myriad of functional elements that control various… Expand
Widespread RNA editing dysregulation in brains from autistic individuals
- Stephen S. Tran, Hyun-Ik Jun, +12 authors X. Xiao
- Biology, Medicine
- Nature Neuroscience
- 17 December 2018
Transcriptomic analyses of postmortem brains have begun to elucidate molecular abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in synaptic development, RNA… Expand
Variation in single-nucleotide sensitivity of eCLIP derived from reverse transcription conditions.
- Eric L. Van Nostrand, A. Shishkin, G. Pratt, T. Nguyen, Gene W. Yeo
- Biology, Medicine
- 15 August 2017
Crosslinking and immunoprecipitation (CLIP) followed by high-throughput sequencing identifies the binding sites of RNA binding proteins on RNAs. The covalent RNA-amino acid adducts produced by UV… Expand
Self-reported fears in Hispanic youth with mental retardation: a preliminary study.
There is a paucity of research on the frequency, intensity, and content of fears experienced by Hispanic (or Latino) American youth with mental retardation. We assessed fears experienced by 48… Expand
Collaborating to Compete: Blood Profiling Atlas in Cancer (BloodPAC) Consortium
- R. Grossman, B. Abel, +77 authors LC Leiman
- Clinical pharmacology and therapeutics
- 12 April 2017
The cancer community understands the value of blood profiling measurements in assessing and monitoring cancer. We describe an effort among academic, government, biotechnology, diagnostic, and… Expand
Drug Interactions with Cobicistat- or Ritonavir-Boosted Elvitegravir.
Cobicistat and ritonavir are structurally distinct compounds that both potently inhibit cytochrome P450 (CYP) 3A, the metabolizing enzyme primarily responsible for the elimination of several… Expand