Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
- H. Ott, Thomas S Matthiesen, D. Taylor
- Biology, MedicineNature Network Boston
- 1 February 2008
Eight constructs decellularized hearts by coronary perfusion with detergents, preserved the underlying extracellular matrix, and produced an acellular, perfusable vascular architecture, competent a cellular valves and intact chamber geometry that could generate pump function in a modified working heart preparation.
Sniffing controls an adaptive filter of sensory input to the olfactory bulb
- J. V. Verhagen, D. Wesson, T. Netoff, J. White, M. Wachowiak
- Biology, PsychologyNature Neuroscience
- 1 May 2007
An unexpected functional role for sniffing is suggested and sensory codes can be transformed by sampling behavior alone is shown, suggesting an adaptive filter for detecting changes in the odor landscape.
Seizure prediction with spectral power of EEG using cost‐sensitive support vector machines
A patient‐specific algorithm for seizure prediction using multiple features of spectral power from electroencephalogram (EEG) and support vector machine (SVM) classification is proposed.
Synchronization in hybrid neuronal networks of the hippocampal formation.
The results imply that excitatory SCs, but not inhibitory O-LM interneurons, are capable of synchronizing in phase via monosynaptic mutual connections of the biologically appropriate polarity.
Epilepsy in Small-World Networks
- T. Netoff, R. Clewley, Scott Arno, T. Keck, J. White
- Biology, Computer ScienceJournal of Neuroscience
- 15 September 2004
This mathematical description explains how specific changes in the topology or synaptic strength in the model cause transitions from normal to seizing and then to bursting, which appear to be general properties of excitatory networks.
Beyond Two-Cell Networks: Experimental Measurement of Neuronal Responses to Multiple Synaptic Inputs
- T. Netoff, Corey D. Acker, Jonathan C. Bettencourt, J. White
- BiologyJournal of Computational Neuroscience
- 1 June 2005
The feasibility of extending phase response curve methods to predict the synchronization properties of stellate cells in the rat entorhinal cortex under broader conditions is explored and it is found that models based on weak coupling account for scaling and Poisson process-driven inputs reasonably accurately.
Identification of the hippocampal input to medial prefrontal cortex in vitro.
- M. Parent, Lang Wang, Jianjun Su, T. Netoff, Li-Lian Yuan
- BiologyCerebral Cortex
- 1 February 2010
The identified bundle contains afferent fibers primarily from the ventral hippocampus but does not include contributions from the mediodorsal nucleus of the thalamus, amygdala, or lateral hypothalamus/medial forebrain bundle, which provides the necessary groundwork for the characterization of the hippocampal pathway projecting to the mPFC.
Experimentally Estimating Phase Response Curves of Neurons: Theoretical and Practical Issues
- T. Netoff, M. Schwemmer, T. J. Lewis
- Biology
- 2012
This chapter considers many of the complicating factors that arise when generating PRCs for real neurons or “realistic” model neurons and describes an alternative method to generate PRCs using small amplitude white noise stimuli.
Electric field suppression of epileptiform activity in hippocampal slices.
- B. Gluckman, E. J. Neel, T. Netoff, W. Ditto, M. Spano, S. Schiff
- BiologyJournal of Neurophysiology
- 1 December 1996
Modulation of neuronal activity in these experiments was readily observed at field strengths < or = 5-10 mV/mm and in vivo application of these results may be feasible.
Synchronization from Second Order Network Connectivity Statistics
- Liqiong Zhao, Bryce Beverlin, T. Netoff, D. Nykamp
- Computer ScienceFrontiers in Computational Neuroscience
- 8 July 2011
The synchrony analysis takes advantage of the framework of second order networks, which defines four second order connectivity statistics based on the relative frequency of two-connection network motifs, and identifies two of them, convergent connections, and chain connections, as highly influencing the synchrony.
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