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Identification of a Novel Small Molecule HIF-1α Translation Inhibitor
- T. Narita, Shaoman Yin, +4 authors Erwin G. Van Meir
- Biology, Medicine
- Clinical Cancer Research
- 1 October 2009
Results show that KC7F2 is a potent HIF-1 pathway inhibitor and its potential as a cancer therapy agent warrants further study. Expand
Mechanism of the induction of autoimmune disease by graft-versus-host reaction. Role of CD8+ cells in the development of hepatic and ductal lesions induced by CD4+ cells in MHC class I plus…
- K. Suzuki, T. Narita, R. Yui, H. Asakura, M. Fujiwara
- Biology, Medicine
- Laboratory investigation; a journal of technical…
- 1 May 1994
The results suggest that destructive hepatic lesions of PBC might progress through CD8+ cells in cooperation with CD4+ cells, and that host type CD8- cells could act as "regulatory" T cells for the progression of the lesions. Expand
Telomerase enzyme activity and RNA expression in adriamycin-resistant human breast carcinoma MCF-7 cells.
An unusual reaction of telomerase activity in AdrR may explain, at least in part, one of the mechanisms of the malignant biological behavior related with the drug-resistance to ADM. Expand
The effects of ICRF-154 in combination with other anticancer agents in vitro.
The results indicate that the combined effects of ICRF-154 with other agents vary, depending on the cell line, and that methotrexate is least suitable for such combined treatment. Expand
Concentric fibrosis and cellular infiltration around bile ducts induced by graft-versus-host reaction in mice: a role of CD8+ cells.
It is suggested that CD8+ T lymphocytes might play an important role in the induction of fibrotic lesions in the liver of mice undergoing specified graft-versus-host reaction (GVHR). Expand
Induction of intestinal lesions in nu/nu mice induced by transfer of lymphocytes from syngeneic mice infected with murine retrovirus
Lymphocytes of the virus infected mice induced colitis and hyperplasia of intestinal epithelial cells as well as systemic exocrinopathy in nu/nu mice. Expand
Monday, 27 August 2012
[Carbohydrate antigens as a tumor-associated antigen and prognostic indicators in carcinomas of the breast, esophagus, stomach, colorectum, and pancreas].
In colorectal cancer, the patients with high degree of expression of CA19-9 had a poor prognosis, and high risk of distant metastasis, and higher intensity of staining was observed in hepatic in comparison with primary lesion, thus carbohydrate antigens showed important role as tumor-associated antigen and good indicator for evaluation of prognosis. Expand
Induction of autoimmune-like hepatic and ductal lesions by administration of lipopolysaccharide in mice undergoing graft-versus-host reaction across MHC class I difference.
The induction of autoimmune-like histologic changes in the liver and other organs of mice undergoing graft-versus-host reaction with MHC class I disparity by the administration of bacterial lipopolysaccharide (LPS) is examined to indicate that LPS might be one of the potential factors which augment autoimmune- like lesions. Expand
New Advanced Training Simulator Design for Power System Operations
Abstract In order to prevent human error, the importance of training and improving the skills of personnel involved in operations and maintenance can never be overly emphasized. First, this paper… Expand