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Effects of 4-hydroxyantipyrine and its 4-O-sulfate on antipyrine as biodistribution promoter.
Results suggested that 4-OH could be used as a biodistribution promoter and the enhancement of the blood-brain barrier (BBB) permeability of antipyrine caused by the concomitant use of 4- OH was believed to be concerned with the increase of the Kp value of antipyrsine in the brain. Expand
Mechanism of gastrointestinal absorption of glycyrrhizin in rats.
Although GZ was poorly absorbable, both GZ and GA were detected in rat plasma after oral administration of GZ, suggesting that GZ can be absorbed in both parent and metabolite forms, although their bioavailabilities were low. Expand
Drug absorption from large intestine: physicochemical factors governing drug absorption.
It was shown that the absorption rates in the small intestine tended to reach a ceiling at the high lipophilicity, and it was suggested that the paracellular route for drug penetration in the large intestine is restricted more than in thesmall intestine. Expand
Functions of semaphorins in axon guidance and neuronal regeneration.
Sema3A is now recognized as the most potent repulsive molecule inhibiting or repelling neurite outgrowth, and determining how these repulsive molecules exert their actions has the potential of uncovering new therapeutic approaches to injury and/or degeneration of neuronal tissues. Expand
Gastrointestinal absorption characteristics of glycyrrhizin from glycyrrhiza extract.
The differences in gastrointestinal absorption behaviors of glycyrrhizin between pure GZ and GZ in glycyRrhiza extract (GE) (equivalent dose as GZ) were examined in rats, and at least some of the factors in GE altering the bioavailability of GZ were identified. Expand
Pharmacokinetics of tolbutamide following intravenous and oral administrations in rats with obstructive jaundice.
The pharmacokinetics of tolbutamide following intravenous and oral administration was compared between normal rats and rats with experimentally-induced obstructive jaundice, and showed no change in the elimination rate constant, but a significant increase in the volume of distribution in the OJ state. Expand
Pharmacokinetics of cefpiramide in rats with obstructive jaundice.
Changes in the mode of drug excretion in obstructive jaundice (OJ) were investigated in rats with experimentally induced OJ using a non-metabolized, highly-biliary-excreted antibiotic, cefpiramideExpand
Pharmacokinetics of glycyrrhizin in rats with D-galactosamine-induced hepatic disease.
The pharmacokinetic behavior of glycyrrhizin (GZ) was examined in D-galactosamine-intoxicated (GAL) rats and the AUC for glycyrrhetic acid after oral administration of GZ was higher in GAL rats than in normal rats, although there was no significant difference in MRT or Tmax, Cpmax or the bioavailability for GA between GAL and normal rats. Expand
Biopharmaceutical evaluation of salicylazosulfanilic acid as a novel colon-targeted prodrug of 5-aminosalicylic acid.
The beneficial characteristics of SASA as an excellent colon-targeted prodrug of 5-ASA were clarified and it was confirmed that SASA is free from the liberation of sulfapyridine, the adverse effect moiety of SASP, and less absorbable in the small intestine. Expand
Intestinal absorption of drugs in rats with glycerol-induced acute renal failure.
The intestinal absorption of drugs was investigated in rats with glycerol-induced renal failure by an in situ loop method and the enhancement of membrane permeability was seen in the brush border membrane vesicles prepared from the small intestine of rats with renal failure. Expand