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Programmed cell death protein 1 expression is an independent prognostic factor in gastric cancer after curative resection
BackgroundProgrammed cell death protein 1 (PD-1) and its ligand PD-L1 downregulate T cell activation and are related to immune tolerance. The aim of this study was to clarify the significance of PD-1Expand
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Irinotecan injures tight junction and causes bacterial translocation in rat.
BACKGROUND Tight junctions are an essential component of intestinal epithelial barriers. Claudin-1, occludin, and ZO-1 are the components of tight junction. The purpose of this study was toExpand
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Expression of thrombospondin-1 and Ski are prognostic factors in advanced gastric cancer
BackgroundIt has been suggested that thrombospondin-1 (TSP-1) plays a role in angiogenesis in many cancers. In addition, TSP-1 has been shown to suppress tumor growth by activating transformingExpand
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Prediction of response to preoperative chemoradiotherapy and establishment of individualized therapy in advanced rectal cancer.
Preoperative chemoradiotherapy (CRT) has become the standard treatment for patients with locally advanced rectal cancer. However, no specific biomarker has been identified to predict a response toExpand
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Intraperitoneal infusion of paclitaxel with S-1 for peritoneal metastasis of advanced gastric cancer: phase I study.
BACKGROUND Intraperitoneal administration of taxanes revealed excellent anti-tumor effect for peritoneal metastasis of gastric cancer in some experimental models. The aim of this study is toExpand
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The relationship of CD133, histone deacetylase 1 and thrombospondin-1 in gastric cancer.
BACKGROUND/AIM Gastric cancer is one of the most common types of cancer. Cancer stem cells (CSCs) have been reported to play important roles in multiple cancer types. This study investigated theExpand
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Limited lymph node dissection in elderly patients with gastric cancer.
BACKGROUND The number of elderly patients with gastric cancer is continuing to increase along with the life expectancy of the general population. The purpose of this study was to investigate both theExpand
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Kampo medicine “Dai-kenchu-to” prevents CPT-11-induced small-intestinal injury in rats
PurposeThe key anticancer agent, CPT-11 (irinotecan hydrochloride), induces severe diarrhea clinically. We investigated the effect of a Kampo medicine, Dai-kenchu-to (DKT), on CPT-11-inducedExpand
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Huge splenic epidermoid cyst with elevation of serum CA19-9 level.
A 30-year-old female was referred to our hospital for further examination of liver dysfunction. A huge, soft mass was noted in her left upper quadrant on physical examination. AbdominalExpand
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Predictive factors of peritoneal metastasis in gastric cancer.
BACKGROUND Preoperative radiological diagnosis of gastric cancer with peritoneal metastasis is still incomplete. Staging laparoscopy is performed for patients who are diagnosed T3 or T4Expand
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