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Role and interaction of connective tissue growth factor with transforming growth factor‐β in persistent fibrosis: A mouse fibrosis model
TLDR
It appears that interaction of several growth factors is required for persistent fibrotic tissue formation, with TGF‐β causing the induction and CTGF needed for maintenance of skin fibrosis. Expand
Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy
TLDR
TGF-beta1-CTGF pathway may play a role in the fibrosis that is commonly observed in muscular dystrophy. Expand
Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo.
TLDR
Findings indicate that CTGF is a novel, potent angiogenesis factor which functions in multi-stages in this process. Expand
Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis.
TLDR
Serum CTGF levels were increased in patients with SSc, and correlated with the extent of skin sclerosis and the severity of pulmonary fibrosis, and data suggest that CTGF plays a critical role in the development of fibrosis in SSc. Expand
Type II alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF.
TLDR
In both an autocrine and a paracrine manner, type II alveolar epithelial cells and activated fibroblasts may play a critical role in pulmonary fibrosis by producing connective tissue growth factor which modulates fibroblast proliferation and extracellular matrix production. Expand
Inhibition of endogenous expression of connective tissue growth factor by its antisense oligonucleotide and antisense RNA suppresses proliferation and migration of vascular endothelial cells.
TLDR
Findings suggest that endogenous CTGF expression is involved in the proliferation and migration of BAE cells, which were stably transfected with expression vectors that generate the antisense RNA of CTGF cDNA. Expand
Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia.
TLDR
It is confirmed that CTGF was specifically induced in human fibroblasts by TGF-beta but not by PDGF, FGF, IGF-I, or EGF, and found that the serum levels of CTGF were significantly correlated with the progression of hepatic fibrosis in biliary atresia. Expand
Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells
TLDR
Important roles of CCN2/CTGF in the development and regeneration of periodontal tissue including theperiodontal ligament are suggested. Expand
Cloning of a mRNA preferentially expressed in chondrocytes by differential display-PCR from a human chondrocytic cell line that is identical with connective tissue growth factor (CTGF) mRNA.
TLDR
Findings suggest that CTGF participates in endochondral ossification and is expressed only in the hypertrophic chondrocytes of costal cartilage and the vertebral column in embryonic mice. Expand
Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture.
TLDR
Results indicate that CTGF/Hcs24 directly promotes the proliferation and differentiation of chondrocytes and effectively increased alkaline phosphatase activity in RGC cells in culture. Expand
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