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Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
- Y. Arita, S. Kihara, Y. Matsuzawa
- Biology, MedicineBiochemical and biophysical research…
- 2 April 1999
Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adip onectin is secreted only from adipose tissue.
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.
- K. Hotta, T. Funahashi, Y. Matsuzawa
- Medicine, BiologyArteriosclerosis, thrombosis, and vascular…
- 1 June 2000
Results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy, and weight reduction significantly elevated plasma adip onectin levels in the diabetic subjects as well as the nondiabetic subjects.
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein.
Thiazolidinediones (TZDs) might prevent atherosclerotic vascular disease in insulin-resistant patients by inducing the production of adiponectin through direct effect on its promoter and antagonizing the effect of TNF-alpha on the adiponECTin promoter.
Abdominal fat: standardized technique for measurement at CT.
Although the average CT numbers obtained with different scanners were distributed widely, the calculated fat areas were almost identical, suggesting this method might be a practical and standardized method at CT.
Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin.
Observations suggest that adiponectin modulates endothelial inflammatory response and that the measurement of plasma adiponECTin levels may be helpful in assessment of CAD risk.
Genomic structure and mutations in adipose-specific gene, adiponectin
G/T polymorphism in exon 2 was associated with neither plasma adiponectin concentrations nor the presence of obesity, and a subject carrying missense mutation (R112C) showed markedly low plasma adip onectin concentration.
An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls.
- Y. Okamoto, Y. Arita, Y. Matsuzawa
- BiologyHormone and metabolic research = Hormon- und…
- 1 February 2000
Characteristics of adiponectin in vitro and in vivo suggest that adip onectin is a plasma protein produced by adipose tissue and accumulates in vascular walls when the endothelial barrier is injured.
Pathophysiology and pathogenesis of visceral fat obesity.
- Y. Matsuzawa, I. Shimomura, T. Nakamura, Y. Keno, K. Tokunaga
- MedicineAnnals of the New York Academy of Sciences
- 1 September 1995
A disease entity, visceral fat syndrome, is proposed, which may increase susceptibility to atherosclerosis due to multiple risk factors induced by visceral fat accumulation.
Localization of heparin-binding EGF-like growth factor in the smooth muscle cells and macrophages of human atherosclerotic plaques.
It is suggested that HB-EGF may be implicated in the migration and proliferation of SMC that occurs in the normal development of arterial walls, and in the formation of atherosclerotic plaques.
Aquaporin Adipose, a Putative Glycerol Channel in Adipocytes*
Glycerol release from 3T3-L1 cells was increased during differentiation in parallel with AQPap mRNA levels and suppressed by mercury ion, supporting AQPAP functions as a glycerol channel in adipocytes.