T. Nakamura

Publications71
h-index33
Citations16,651
Highly Influential Citations439
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Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
TLDR
Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adip onectin is secreted only from adipose tissue.
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.
TLDR
Results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy, and weight reduction significantly elevated plasma adip onectin levels in the diabetic subjects as well as the nondiabetic subjects.
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein.
TLDR
Thiazolidinediones (TZDs) might prevent atherosclerotic vascular disease in insulin-resistant patients by inducing the production of adiponectin through direct effect on its promoter and antagonizing the effect of TNF-alpha on the adiponECTin promoter.
Abdominal fat: standardized technique for measurement at CT.
TLDR
Although the average CT numbers obtained with different scanners were distributed widely, the calculated fat areas were almost identical, suggesting this method might be a practical and standardized method at CT.
Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin.
TLDR
Observations suggest that adiponectin modulates endothelial inflammatory response and that the measurement of plasma adiponECTin levels may be helpful in assessment of CAD risk.
Genomic structure and mutations in adipose-specific gene, adiponectin
TLDR
G/T polymorphism in exon 2 was associated with neither plasma adiponectin concentrations nor the presence of obesity, and a subject carrying missense mutation (R112C) showed markedly low plasma adip onectin concentration.
An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls.
TLDR
Characteristics of adiponectin in vitro and in vivo suggest that adip onectin is a plasma protein produced by adipose tissue and accumulates in vascular walls when the endothelial barrier is injured.
Pathophysiology and pathogenesis of visceral fat obesity.
TLDR
A disease entity, visceral fat syndrome, is proposed, which may increase susceptibility to atherosclerosis due to multiple risk factors induced by visceral fat accumulation.
Localization of heparin-binding EGF-like growth factor in the smooth muscle cells and macrophages of human atherosclerotic plaques.
TLDR
It is suggested that HB-EGF may be implicated in the migration and proliferation of SMC that occurs in the normal development of arterial walls, and in the formation of atherosclerotic plaques.
Aquaporin Adipose, a Putative Glycerol Channel in Adipocytes*
TLDR
Glycerol release from 3T3-L1 cells was increased during differentiation in parallel with AQPap mRNA levels and suppressed by mercury ion, supporting AQPAP functions as a glycerol channel in adipocytes.
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