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Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells.
Focal adhesion kinase (FAK) has been implicated in the development of cancers, including those of the breast. Nevertheless, the molecular and cellular mechanisms by which FAK promotes mammary… Expand
Role of FIP200 in cardiac and liver development and its regulation of TNFα and TSC–mTOR signaling pathways
- B. Gan, X. Peng, T. Nagy, A. Alcaraz, H. Gu, J. Guan
- Medicine, Biology
- The Journal of cell biology
- 9 October 2006
Focal adhesion kinase family interacting protein of 200 kD (FIP200) has been shown to regulate diverse cellular functions such as cell size, proliferation, and migration in vitro. However, the… Expand
Cancer progression by reprogrammed BCAA metabolism in myeloid leukemia
Reprogrammed cellular metabolism is a common characteristic observed in various cancers. However, whether metabolic changes directly regulate cancer development and progression remains poorly… Expand
Mammary Epithelial-specific Deletion of the Focal Adhesion Kinase Gene Leads to Severe Lobulo-Alveolar Hypoplasia and Secretory Immaturity of the Murine Mammary Gland*
Integrin-mediated cell adhesion and signaling is required for mammary gland development and functions. As a major mediator of integrin signaling, focal adhesion kinase (FAK) has been implicated to… Expand
Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice.
OBJECTIVE Focal adhesion kinase is implicated in the regulation of cell adhesion, migration, survival, and cell-cycle progression. However, the functions of focal adhesion kinase in endothelial cell… Expand
Atbf1 Regulates Pubertal Mammary Gland Development Likely by Inhibiting the Pro-Proliferative Function of Estrogen-ER Signaling
ATBF1 is a candidate tumor suppressor that interacts with estrogen receptor (ER) to inhibit the function of estrogen-ER signaling in gene regulation and cell proliferation control in human breast… Expand
Specific posttranslational modification regulates early events in mammary carcinoma formation
- H. Guo, H. Johnson, M. Randolph, T. Nagy, R. Blalock, M. Pierce
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 15 November 2010
The expression of an enzyme, GnT-V, that catalyzes a specific posttranslational modification of a family of glycoproteins, namely a branched N-glycan, is transcriptionally up-regulated during breast… Expand
Estrogen receptor α contributes to T cell–mediated autoimmune inflammation by promoting T cell activation and proliferation
Estrogen receptor α promotes T cell activation and exacerbates autoimmune disease. Estrogen receptor stimulates T cells Sex-linked susceptibility has been described for nearly 75% of all autoimmune… Expand
[Surgical cerclage in the treatment of cervical incompetence during pregnancy (determining the legitimacy of the procedure)].
The authors studied the effectiveness of the cervical cerclage operation in the therapy of cervical insufficiency during the pregnancy. Two Hundred sixteen pregnant women took part in this trial in… Expand
Maternal Malaria Induces a Procoagulant and Antifibrinolytic State That Is Embryotoxic but Responsive to Anticoagulant Therapy
Low birth weight and fetal loss are commonly attributed to malaria in endemic areas, but the cellular and molecular mechanisms that underlie these poor birth outcomes are incompletely understood.… Expand