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Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells.
It is found that Stat5 phosphorylation in T cells is suppressed in the presence of MSCs and that nitric oxide (NO) is involved in the suppression of Stat5osphorylation and T-cell proliferation, and that NO produced by Mscs is one of the major mediators of T- cell suppression by M SCs. Expand
Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: the JALSG AML201 Study.
High-dose daunorubsicin and standard-dose idarubicin were equally effective for the treatment of adult acute myeloid leukemia, achieving a high rate of complete remission and good long-term efficacy. Expand
The role of heme in gene expression.
In mammals, ALAS activity can be found in many tissues, the highest activity being found in the Harderian gland in rodents, the liver of chemically induced porphyric animals, and developing erythroblasts. Expand
A randomized comparison of 4 courses of standard-dose multiagent chemotherapy versus 3 courses of high-dose cytarabine alone in postremission therapy for acute myeloid leukemia in adults: the JALSG…
It is demonstrated that the multiagent CT regimen is as effective as the HiDAC regimen for consolidation on disease-free survival only in the favorable cytogenetic leukemia group. Expand
Bortezomib overcomes cell adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma
Functional screening using short hairpin RNA suggests that VLA-4 plays a critical role in CAM-DR of MM cells, and the combination of bortezomib with conventional anti-myeloma drugs may be effective in overcoming CAM- DR of MM. Expand
Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line.
Changes in the redox state caused by antioxidants such as ascorbic acid can overcome resistance to imatinib via inhibition of Nrf2-mediated gene expression. Expand
Regulation of NF-E2 Activity in Erythroleukemia Cell Differentiation*
- T. Nagai, K. Igarashi, +5 authors S. Sassa
- Biology, Medicine
- The Journal of Biological Chemistry
- 27 February 1998
It is suggested that a MafK homodimer can suppress transcription, not only by competition for the DNA binding site, but also by direct inhibition of transcription. Expand
Severe Hepatitis and Complete Molecular Response Caused by Imatinib Mesylate: Possible Association of Its Serum Concentration with Clinical Outcomes
Results suggest that both hepatitis and molecular response were associated with the serum STI571 concentration, which is consistent with drug-induced hepatitis. Expand
Transcription factor GATA-2 is expressed in erythroid, early myeloid, and CD34+ human leukemia-derived cell lines.
The expression profile of Gata-2 is consistent with the hypothesis that GATA-2 plays unique roles for the transcriptional activation of genes in cells at an early stage of hematopoietic differentiation and in developing cells of the erythroid and myeloid lineages. Expand
Hemin reduces cellular sensitivity to imatinib and anthracyclins via Nrf2
- T. Nagai, S. Kikuchi, +6 authors K. Ozawa
- Chemistry, Medicine
- Journal of cellular biochemistry
- 15 May 2008
Cellular heme level plays an important role in determining the sensitivity of cells to imatinib and certain other anti‐leukemia drugs and that the effect of heme may be mediated via its ability to upregulate Nrf2 activity. Expand