• Publications
  • Influence
Endothelin-1 induces release of histamine and leukotriene C4 from mouse bone marrow-derived mast cells.
Whether specific binding sites for endothelin-1 and endothelin-3 exist in mouse bone marrow-derived mast cells (BMMC) and if these endothelins are capable of stimulating chemical mediator releaseExpand
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Atopic dermatitis‐like pruritic skin inflammation caused by feeding a special diet to HR‐1 hairless mice
Abstract:  Dry skin/barrier dysfunction is considered to be one of the characteristic features of atopic dermatitis (AD). When HR‐1 hairless mice are fed a special diet, HR‐AD, dry red skin isExpand
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Pulmonary emphysema induced by cigarette smoke solution and lipopolysaccharide in guinea pigs.
Exposure of animals to cigarette smoke for longer than 3 months leads to the development of chronic obstructive pulmonary disease (COPD) showing pulmonary emphysema. We attempted to create a COPDExpand
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Interleukin (IL)-33: new therapeutic target for atopic diseases.
  • T. Nabe
  • Medicine
  • Journal of pharmacological sciences
  • 20 October 2014
Interleukin (IL)-33, a member of the IL-1 family of cytokines, is produced when epithelial and endothelial cells are exposed to stimuli. Hematopoietic cells such as macrophages also produce IL-33.Expand
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Repeated antigen inhalation-induced reproducible early and late asthma in guinea pigs.
To develop a model of chronic experimental asthma in guinea pigs, the animal was forced to inhale the mist of a low dose of ovalbumin (OA) adsorbed on fine Al(OH)3 for sensitization once every 4Expand
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Dimaprit, a histamine H2-agonist, inhibits anaphylactic histamine release from mast cells and the decreased release is restored by thioperamide (H3-antagonist), but not by cimetidine (H2-antagonist).
Whether anaphylactic histamine release from rat peritoneal mast cells is influenced by betahistine, a histamine H1-receptor agonist/H3-antagonist, and dimaprit, an H2-agonist, was examined. TreatmentExpand
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Markedly increased nasal blockage by intranasal leukotriene D4 in an experimental allergic rhinitis model: contribution of dilated mucosal blood vessels.
We examined whether nasal hyperresponsiveness to leukotriene (LT) D4 is seen in our allergic rhinitis model, which showed sneezing and biphasic nasal blockage by repeated antigen inhalationExpand
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Involvement of thromboxane A2 and peptide leukotrienes in early and late phase nasal blockage in a guinea pig model of allergic rhinitis
Abstract. Objective and design: We investigated the effects of the thromboxane (TX) A2 antagonist seratrodast, the peptide leukotriene (p-LT) antagonist pranlukast, the antihistaminic drugExpand
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Nasal hyperresponsiveness to histamine induced by repetitive exposure to cedar pollen in guinea-pigs.
Nasal hyperresponsiveness is one of the characteristic features of the pathogenesis of allergic rhinitis. This study examined whether repetitive inhalation of antigen (Japanese cedar pollen) led toExpand
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Endothelin-1, one of the most potent histamine releasers in mouse peritoneal mast cells.
Whether endothelin-1 or -3 is capable of inducing histamine release from the peritoneal mast cells of BALB/c mice was investigated in vitro and compared to the release induced by compound 48/80. InExpand
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