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Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes
The causative agent of malaria, Plasmodium, replicates inside a membrane-bound parasitophorous vacuole (PV), which shields this intracellular parasite from the cytosol of the host cell1. One commonExpand
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Fusion Inhibitory Lipopeptides Engineered for Prophylaxis of Nipah Virus in Primates
Antiviral peptides for Nipah virus can be administered prophylactically by the respiratory route, targeted to the respiratory tract, and provide protection to hamsters and nonhuman primates fromExpand
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In Vivo Efficacy of Measles Virus Fusion Protein-Derived Peptides Is Modulated by the Properties of Self-Assembly and Membrane Residence
ABSTRACT Measles virus (MV) infection is undergoing resurgence and remains one of the leading causes of death among young children worldwide despite the availability of an effective measles vaccine.Expand
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Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance
Understanding the interplay between molecules and lipid membranes is fundamental when studying cellular and biotechnological phenomena. Partition between aqueous media and lipid membranes is key toExpand
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Self-assembly Stability Compromises the Efficacy of Tryptophan-Containing Designed Anti-measles Virus Peptides
The resurgence of several infectious diseases, like measles, has driven the search for new chemotherapeutics to prevent and treat viral infections. Self-assembling antiviral peptides are a promisingExpand
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Effective in Vivo Targeting of Influenza Virus through a Cell-Penetrating/Fusion Inhibitor Tandem Peptide Anchored to the Plasma Membrane.
The impact of influenza virus infection is felt each year on a global scale when approximately 5-10% of adults and 20-30% of children globally are infected. While vaccination is the primary strategyExpand
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Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors
Objective:To develop a novel and potent fusion inhibitor of HIV infection based on a rational strategy for synthetic antibody library construction. Design:The reduced molecular weight ofExpand
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Structure-Stability-Function Mechanistic Links in the Anti-Measles Virus Action of Tocopherol-Derivatized Peptide Nanoparticles.
Measles remains one of the leading causes of child mortality worldwide and is re-emerging in some countries due to poor vaccine coverage, concomitant with importation of measles virus (MV) fromExpand
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The interaction of antibodies with lipid membranes unraveled by fluorescence methodologies
Abstract The interest and investment in antibody therapies has reached an overwhelming scale in the last decade. Yet, little concern has been noticed among the scientific community to unravelExpand
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Plant defensin PvD1 modulates the membrane composition of breast tumour-derived exosomes.
One of the most important causes of failure in tumour treatment is the development of resistance to therapy. Cancer cells can develop the ability to lose sensitivity to anti-neoplastic drugs duringExpand
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